Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7pbd
Q-score: 0.485
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS
Nature (2022) 602 pp. 529-533 [ DOI: doi:10.1038/s41586-022-04402-z Pubmed: 35140402 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gaba-a receptor - megabody 25 complex (220 kDa, Complex)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Megabody 25 (Complex from Lama glama)
- Histamine (111 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Gaba-a receptor (Complex from Homo sapiens)
- Megabody 25 (56 kDa, Protein from Lama glama)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 7pbz
Q-score: 0.548
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS
Nature (2022) 602 pp. 529-533 [ DOI: doi:10.1038/s41586-022-04402-z Pubmed: 35140402 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hexane (86 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gaba-a receptor - megabody 25 complex (220 kDa, Complex)
- Undecane (156 Da, Ligand)
- Megabody 25 (Complex from Lama glama)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Histamine (111 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Gaba-a receptor (Complex from Homo sapiens)
- Megabody 25 (56 kDa, Protein from Lama glama)
GABA-A receptor bound by a-Cobratoxin
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7pc0
Q-score: 0.489
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS
Nature (2022) 602 pp. 529-533 [ DOI: doi:10.1038/s41586-022-04402-z Pubmed: 35140402 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Hexane (86 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gaba-a receptor pentamer (Complex from Homo sapiens)
- Megabody 25 (Complex from Lama glama)
- Histamine (111 Da, Ligand)
- Cobratoxin (Complex from Naja kaouthia)
- Alpha-cobratoxin (7 kDa, Protein from Naja kaouthia)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Gaba-a receptor pentamer bound by cobratoxin (240 kDa, Complex)
- Megabody 25 (56 kDa, Protein from Lama glama)