momSalB bound Kappa Opioid Receptor in complex Gi1
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
momSalB bound Kappa Opioid Receptor in complex with GoA
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
momSalB bound Kappa Opioid Receptor in complex with Gi1
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8dzp
Q-score: 0.533
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Methyl (2s,4ar,6ar,7r,9s,10as,10br)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2h-naphtho[2,1-c]pyran-7-carboxylate (434 Da, Ligand)
- Momsalb bound kappa opioid receptor in complex with gi1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
momSalB bound Kappa Opioid Receptor in complex with GoA
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8dzq
Q-score: 0.459
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Methyl (2s,4ar,6ar,7r,9s,10as,10br)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2h-naphtho[2,1-c]pyran-7-carboxylate (434 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Momsalb bound kappa opioid receptor in complex with goa (Complex from Homo sapiens)
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8dzr
Q-score: 0.485
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gr89,696 bound kappa opioid receptor in complex with gustducin (Complex from Homo sapiens)
- Kappa-type opioid receptor (32 kDa, Protein from Homo sapiens)
- Methyl (3r)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate (414 Da, Ligand)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G alpha gustducin protein (40 kDa, Protein from Homo sapiens)
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8dzs
Q-score: 0.531
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(z) subunit alpha (39 kDa, Protein from Homo sapiens)
- Methyl (3r)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate (414 Da, Ligand)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gr89,696 bound kappa opioid receptor in complex with gz (Complex from Homo sapiens)