momSalB bound Kappa Opioid Receptor in complex Gi1
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
momSalB bound Kappa Opioid Receptor in complex with GoA
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
momSalB bound Kappa Opioid Receptor in complex with Gi1
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8dzp
Q-score: 0.533
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Momsalb bound kappa opioid receptor in complex with gi1 (Complex from Homo sapiens)
- Methyl (2s,4ar,6ar,7r,9s,10as,10br)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2h-naphtho[2,1-c]pyran-7-carboxylate (434 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
momSalB bound Kappa Opioid Receptor in complex with GoA
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8dzq
Q-score: 0.459
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Methyl (2s,4ar,6ar,7r,9s,10as,10br)-2-(furan-3-yl)-9-(methoxymethoxy)-6a,10b-dimethyl-4,10-dioxododecahydro-2h-naphtho[2,1-c]pyran-7-carboxylate (434 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Momsalb bound kappa opioid receptor in complex with goa (Complex from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
GR89,696 bound Kappa Opioid Receptor in complex with gustducin
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8dzr
Q-score: 0.485
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Methyl (3r)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate (414 Da, Ligand)
- Kappa-type opioid receptor (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gr89,696 bound kappa opioid receptor in complex with gustducin (Complex from Homo sapiens)
- G alpha gustducin protein (40 kDa, Protein from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8dzs
Q-score: 0.531
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Nature (2023) 617 pp. 417-425 [ DOI: doi:10.1038/s41586-023-06030-7 Pubmed: 37138078 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Methyl (3r)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate (414 Da, Ligand)
- Guanine nucleotide-binding protein g(z) subunit alpha (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 protein (26 kDa, Protein from Mus musculus)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Gr89,696 bound kappa opioid receptor in complex with gz (Complex from Homo sapiens)
C6-guano bound Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7u2k
Q-score: 0.527
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S
Nature (2023) 613 pp. 767-774 [ DOI: doi:10.1038/s41586-022-05588-y Pubmed: 36450356 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- N-(6-carbamimidamidohexyl)-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (401 Da, Ligand)
- C6guano bound mu opioid receptor-gi protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 7sk2
Q-score: 0.335
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C
Nature (2022) 606 pp. 820-826 [ Pubmed: 35676483 DOI: doi:10.1038/s41586-022-04814-x ]
- Gat-1 in complex with tiagabine (67 MDa, Complex from Homo sapiens)
- Tiagabine (375 Da, Ligand)
- Sodium- and chloride-dependent gaba transporter 1 (64 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7u2l
Q-score: 0.525
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S
Nature (2023) 613 pp. 767-774 [ DOI: doi:10.1038/s41586-022-05588-y Pubmed: 36450356 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5guano-uor-gi-scfv16 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- N-(5-carbamimidamidopentyl)-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (387 Da, Ligand)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 6uo8
Q-score: 0.447
Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V
Nature (2020) 584 pp. 298-303 [ DOI: doi:10.1038/s41586-020-2408-4 Pubmed: 32555460 ]
- (r)-(3-aminopropyl)methylphosphinic acid (137 Da, Ligand)
- N~4~,n~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine (337 Da, Ligand)
- Gaba(b) receptor bound to agonist and pam (174 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid type b receptor subunit 1 (86 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid type b receptor subunit 2 (88 kDa, Protein from Homo sapiens)