Cryo-EM structure of Sevenless extracellular domain (monomer)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless in complex with Bride of Sevenless
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
- Protein sevenless (225 kDa, Protein from Drosophila melanogaster)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein bride of sevenless (57 kDa, Protein from Drosophila melanogaster)
- Sevenless extracellular domain in complex with bride of sevenless extracellular domain (Complex from Drosophila melanogaster)
Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless extracellular domain (dimer, pH 6.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless extracellular domain (composite map of the dimer, pH 4.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of LRP2 at pH 7.5
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8em4
Q-score: 0.36
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
- Lrp2 at neutral ph (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of LRP2 at pH 5.2
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8em7
Q-score: 0.423
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lrp2 at endosomal ph (Complex from Mus musculus)
Local refinement map of LRP2 P1-P2 domains at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
Local refinement of P3-P6 domains of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
Local refinement of the P7 domain of LRP2 at pH 7.5
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821-836.e13 [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]