Cryo-EM structure of Sevenless extracellular domain (monomer)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ Pubmed: 39510067 DOI: doi:10.1016/j.molcel.2024.10.017 ]
Cryo-EM structure of Sevenless in complex with Bride of Sevenless
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ Pubmed: 39510067 DOI: doi:10.1016/j.molcel.2024.10.017 ]
- Sevenless extracellular domain in complex with bride of sevenless extracellular domain (Complex from Drosophila melanogaster)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein sevenless (225 kDa, Protein from Drosophila melanogaster)
- Protein bride of sevenless (57 kDa, Protein from Drosophila melanogaster)
Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ Pubmed: 39510067 DOI: doi:10.1016/j.molcel.2024.10.017 ]
Cryo-EM structure of Sevenless extracellular domain (dimer, pH 6.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ Pubmed: 39510067 DOI: doi:10.1016/j.molcel.2024.10.017 ]
Cryo-EM structure of Sevenless extracellular domain (composite map of the dimer, pH 4.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ Pubmed: 39510067 DOI: doi:10.1016/j.molcel.2024.10.017 ]
Cryo-EM structure of LRP2 at pH 7.5
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8em4
Q-score: 0.36
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
- Lrp2 at neutral ph (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
Cryo-EM structure of LRP2 at pH 5.2
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8em7
Q-score: 0.423
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ DOI: doi:10.1016/j.cell.2023.01.016 Pubmed: 36750096 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
- Lrp2 at endosomal ph (Complex from Mus musculus)
Omicron spike trimer bound with P3E6 (Local Refinement)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ykj
Q-score: 0.369
Luo M, Zhou B, Reddem ER, Tang B, Chen B, Zhou R, Liu H, Liu L, Katsamba PS, Au KK, Man HO, To KK, Yuen KY, Shapiro L, Dang S, Ho DD, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2146538-2146538 [ Pubmed: 36354024 DOI: doi:10.1080/22221751.2022.2146538 ]
- Spike glycoprotein (Complex from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P3e6 heavy chain (13 kDa, Protein from Homo sapiens)
- P3e6 heavy chain,p3e6 light chain (Complex)
- P3e6 light chain (11 kDa, Protein from Homo sapiens)
- The complex of omicron spike trimer bound with p3e6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8dxs
Q-score: 0.291
Luo M, Zhou B, Reddem ER, Tang B, Chen B, Zhou R, Liu H, Liu L, Katsamba PS, Au KK, Man HO, To KK, Yuen KY, Shapiro L, Dang S, Ho DD, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2146538-2146538 [ Pubmed: 36354024 DOI: doi:10.1080/22221751.2022.2146538 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- P2b4 heavy chain (24 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with p2b4 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- P2b4 light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7rw2
Q-score: 0.386
Cerutti G, Guo Y, Wang P, Nair MS, Wang M, Huang Y, Yu J, Liu L, Katsamba PS, Bahna F, Reddem ER, Kwong PD, Ho DD, Sheng Z, Shapiro L
Cell Rep (2021) 37 pp. 109928-109928 [ Pubmed: 34706271 DOI: doi:10.1016/j.celrep.2021.109928 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-7 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 5-7 heavy chain (27 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 5-7 light chain (23 kDa, Protein from Homo sapiens)