Cryo-EM structure of Sevenless extracellular domain (monomer)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless in complex with Bride of Sevenless
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
- Protein sevenless (225 kDa, Protein from Drosophila melanogaster)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein bride of sevenless (57 kDa, Protein from Drosophila melanogaster)
- Sevenless extracellular domain in complex with bride of sevenless extracellular domain (Complex from Drosophila melanogaster)
Cryo-EM structure of Bride of Sevenless extracellular domain (dimer, Sevenless-bound form)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless extracellular domain (dimer, pH 6.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of Sevenless extracellular domain (composite map of the dimer, pH 4.6)
Cerutti G, Arias R, Bahna F, Mannepalli S, Katsamba PS, Ahlsen G, Kloss B, Bruni R, Tomlinson A, Shapiro L
Mol Cell (2024) 84 pp. 4677-4690.e6 [ DOI: doi:10.1016/j.molcel.2024.10.017 Pubmed: 39510067 ]
Cryo-EM structure of LRP2 at pH 7.5
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8em4
Q-score: 0.36
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
- Lrp2 at neutral ph (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of LRP2 at pH 5.2
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8em7
Q-score: 0.423
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L
Cell (2023) 186 pp. 821- [ Pubmed: 36750096 DOI: doi:10.1016/j.cell.2023.01.016 ]
- 2-acetamido-2-deoxy-beta-d-galactopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Low-density lipoprotein receptor-related protein 2 (519 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lrp2 at endosomal ph (Complex from Mus musculus)
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8dxs
Q-score: 0.291
Luo M, Zhou B, Reddem ER, Tang B, Chen B, Zhou R, Liu H, Liu L, Katsamba PS, Au KK, Man HO, To KK, Yuen KY, Shapiro L, Dang S, Ho DD, Chen Z
Emerg Microbes Infect (2023) 12 pp. 2146538-2146538 [ DOI: doi:10.1080/22221751.2022.2146538 Pubmed: 36354024 ]
- Prefusion sars-cov-2 spike glycoprotein in complex with p2b4 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- P2b4 heavy chain (24 kDa, Protein from Homo sapiens)
- P2b4 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7rw2
Q-score: 0.386
Cerutti G, Guo Y, Wang P, Nair MS, Wang M, Huang Y, Yu J, Liu L, Katsamba PS, Bahna F, Reddem ER, Kwong PD, Ho DD, Sheng Z, Shapiro L
Cell Rep (2021) 37 pp. 109928-109928 [ Pubmed: 34706271 DOI: doi:10.1016/j.celrep.2021.109928 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Prefusion sars-cov-2 spike glycoprotein in complex with 5-7 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 5-7 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-7 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7l2d
Q-score: 0.425
Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Cell Host Microbe (2021) 29 pp. 819- [ DOI: doi:10.1016/j.chom.2021.03.005 Pubmed: 33789084 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-87 light chain (22 kDa, Protein from Homo sapiens)
- 1-87 heavy chain (25 kDa, Protein from Homo sapiens)
- Prefusion sars-cov-2 spike glycoprotein in complex with 1-87 fab (Complex from Homo sapiens)