Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic, Original map receptor
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist GB18, Original map receptor
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist GB18, Original map G protein
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vve
Q-score: 0.333
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- (4bs,8r,8as,10as,11r,14as,19ar,20br)-7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,20,20b-dodecahydro-19ah-4,8:11,15-dimethanobis[1]benzofuro[2,3-a:3',2'-i]dipyrido[4,3-b:3',4'-h]carbazole-1,8a,10a,18-tetrol (661 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist norbni (130 kDa, Complex from Homo sapiens)
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vvf
Q-score: 0.428
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- (3r)-7-hydroxy-n-{(2s)-1-[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (465 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vvg
Q-score: 0.386
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01812-0 Pubmed: 39775170 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Methyl (2s,3r,3as,4s,5as,9as,9bs)-3-methyl-2-[(2s,6s)-6-methylpiperidin-2-yl]dodecahydro-3,5a-epoxycyclopenta[a]naphthalene-4-carboxylate (361 Da, Ligand)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic , no scFv16
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 9d61
Q-score: 0.312
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ DOI: doi:10.1038/s41589-024-01812-0 Pubmed: 39775170 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- (3r)-7-hydroxy-n-{(2s)-1-[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (465 Da, Ligand)
Cryo-EM map of close dodecameric CaMKII beta holoenzyme T287A T306A T307A