Kappa opioid receptor:Galphai protein in complex with inverse agonist norBNI
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vve
Q-score: 0.333
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist norbni (130 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (4bs,8r,8as,10as,11r,14as,19ar,20br)-7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,20,20b-dodecahydro-19ah-4,8:11,15-dimethanobis[1]benzofuro[2,3-a:3',2'-i]dipyrido[4,3-b:3',4'-h]carbazole-1,8a,10a,18-tetrol (661 Da, Ligand)
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vvf
Q-score: 0.428
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- (3r)-7-hydroxy-n-{(2s)-1-[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (465 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vvg
Q-score: 0.386
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Methyl (2s,3r,3as,4s,5as,9as,9bs)-3-methyl-2-[(2s,6s)-6-methylpiperidin-2-yl]dodecahydro-3,5a-epoxycyclopenta[a]naphthalene-4-carboxylate (361 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic , no scFv16
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 9d61
Q-score: 0.312
Tyson AS, Khan S, Motiwala Z, Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N, Woo S, Villers K, Landaker D, Kenakin T, Shenvi R, Majumdar S, Gati C
Nat Chem Biol (2025) [ Pubmed: 39775170 DOI: doi:10.1038/s41589-024-01812-0 ]
- (3r)-7-hydroxy-n-{(2s)-1-[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (465 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with heterotrimeric g protein (gai/b/g) and inverse agonist jdtic (130 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of tetradecameric CaMKII beta holoenzyme T287A T306A T307A
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8t6k
Q-score: 0.539
Cryo-EM structure of dodecameric CaMKII beta holoenzyme T287A T306A T307A
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t6q
Q-score: 0.389
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8qu8
Q-score: 0.306
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost AB, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber AA, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A
Science (2024) 385 pp. 1338-1347 [ DOI: doi:10.1126/science.adm8684 Pubmed: 39298590 ]
- Zinc ion (65 Da, Ligand)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- (2s,4r)-1-[(2s)-2-[4-[4-[(3s)-4-[4-[5-[(4s)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5h-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-n-[(1r)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide (1 kDa, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kras/acbi3/vhl/elob/eloc/cul2/rbx1 (168 kDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cullin-2 (86 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (24 kDa, Protein from Homo sapiens)