The structure of NiV L-P complex
Hu S, Kim H, Yang P, Yu Z, Ludeke B, Mobilia S, Pan J, Stratton M, Bian Y, Fearns R, Abraham J
Cell (2025) 188 pp. 688-703.e18 [ Pubmed: 39837328 DOI: doi:10.1016/j.cell.2024.12.021 ]
- Nipah virus the large protein (l) with its cofactor phosphoprotein (p) (580 MDa, Complex from Henipavirus nipahense)
- Zinc ion (65 Da, Ligand)
- Phosphoprotein (78 kDa, Protein from Henipavirus nipahense)
- Rna-directed rna polymerase l (257 kDa, Protein from Henipavirus nipahense)
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8vh4
Q-score: 0.333
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ Pubmed: 39343966 DOI: doi:10.1038/s41467-024-52723-6 ]
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8vh5
Q-score: 0.248
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ Pubmed: 39343966 DOI: doi:10.1038/s41467-024-52723-6 ]
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
Cryo-EM structure of Maltose Binding Protein
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8ybe
Q-score: 0.676
To Be Published
- Maltose/maltodextrin-binding periplasmic protein (40 kDa, Protein from Escherichia coli)
- Maltose binding protein monomer (Complex from Escherichia coli)
- Water (18 Da, Ligand)
The focused refinement of CCT3-PhLP2A from TRiC-PhLP2A complex in the open state
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 8i6j
Q-score: 0.404
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ DOI: doi:10.1038/s41467-024-45242-x Pubmed: 38307855 ]
- Complex of tric/cct and phlp2a (1 MDa, Complex from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- Tric/cct (Complex)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
Human TRiC-PhLP2A complex in the open state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8i9u
Q-score: 0.286
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ DOI: doi:10.1038/s41467-024-45242-x Pubmed: 38307855 ]
- Complex of human tric/cct and phlp2a (1 MDa, Complex)
- Human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- Phlp2a (pdcl3) in human tric/cct complex (Complex from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
Cryo-EM structure of human DICER-pre-miRNA in a dicing state
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7xw2
Q-score: 0.444
Lee YY, Lee H, Kim H, Kim VN, Roh SH
Nature (2023) 615 pp. 331-338 [ DOI: doi:10.1038/s41586-023-05723-3 Pubmed: 36813958 ]
- Rna (73-mer) (23 kDa, RNA from Homo sapiens)
- Endoribonuclease dicer (218 kDa, Protein from Homo sapiens)
- Protein-rna complex of human dicer with pre-mirna (Complex)
- Human dicer (Complex from Homo sapiens)
- Pre-mirna (Complex)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 6pwv
Q-score: 0.188
Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US
Nat Commun (2019) 10 pp. 5540-5540 [ DOI: doi:10.1038/s41467-019-13550-2 Pubmed: 31804488 ]
- Histone h2a type 1 (13 kDa, Protein from Xenopus laevis)
- Wd repeat-containing protein 5 (34 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Dna (147-mer) (45 kDa, DNA from synthetic construct)
- Protein dpy-30 homolog (11 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Dna (147-mer) (45 kDa, DNA from synthetic construct)
- Human mll1 complex bound to the nucleosome (Complex from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Retinoblastoma-binding protein 5 (59 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase 2a (24 kDa, Protein from Homo sapiens)
- Set1/ash2 histone methyltransferase complex subunit ash2 (60 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6pww
Q-score: 0.26
Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US
Nat Commun (2019) 10 pp. 5540-5540 [ DOI: doi:10.1038/s41467-019-13550-2 Pubmed: 31804488 ]
- Histone h2a type 1 (13 kDa, Protein from Xenopus laevis)
- Wd repeat-containing protein 5 (34 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Rbbp5, wdr5, and mll1 in complex with the nucleosome (Complex from Xenopus laevis)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Dna (146-mer) (45 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Histone-lysine n-methyltransferase 2a (24 kDa, Protein from Homo sapiens)
- Retinoblastoma-binding protein 5 (59 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)