Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x6c
Q-score: 0.518
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8gvw
Q-score: 0.44
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8gvx
Q-score: 0.323
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7x6i
Q-score: 0.392
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Trp channel (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- G protein (Complex)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trp channel-g protein complex (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)