Cryo-EM structure of the human P2X3 receptor-compound 26a complex
Kim GR, Kim S, Kim YO, Han X, Nagel J, Kim J, Song DI, Muller CE, Yoon MH, Jin MS, Kim YC
J Med Chem (2024) 67 pp. 14443-14465 [ DOI: doi:10.1021/acs.jmedchem.4c01214 Pubmed: 39102524 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- P2x purinoceptor 3 (40 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human p2x3 receptor-compound 26a complex (Complex from Homo sapiens)
- 4-[2-cyclopropyl-7-[[(1~{r})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide (456 Da, Ligand)
Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8hti
Q-score: 0.583
Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ
Nat Commun (2023) 14 pp. 8105-8105 [ Pubmed: 38062020 DOI: doi:10.1038/s41467-023-43983-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Consensus olfactory receptor or52c (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Complex of consensus olfactory receptor or52c in complex with octanoic acid, g protein and nanobody 35 (nb35) (140 kDa, Complex from Homo sapiens)
- Octanoic acid (caprylic acid) (144 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Consensus Olfactory Receptor OR52c in apo state, OR52c-bRIL
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 8j46
Q-score: 0.365
Human Consensus Olfactory Receptor OR52c in apo state, OR52c only
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8h86
Q-score: 0.661
Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE
Cell (2023) 186 pp. 4325-4344.e26 [ DOI: doi:10.1016/j.cell.2023.08.009 Pubmed: 37652010 ]
- Water (18 Da, Ligand)
- Retinal (284 Da, Ligand)
- (7r,17e,20e)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide (759 Da, Ligand)
- Hckcr1 (Complex from Hyphochytrium catenoides)
- Hckcr1 (31 kDa, Protein from Hyphochytrium catenoides)
- Palmitic acid (256 Da, Ligand)
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8h87
Q-score: 0.682
Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE
Cell (2023) 186 pp. 4325-4344.e26 [ DOI: doi:10.1016/j.cell.2023.08.009 Pubmed: 37652010 ]
- Hckcr2 (34 kDa, Protein from Hyphochytrium catenoides)
- Water (18 Da, Ligand)
- Retinal (284 Da, Ligand)
- (7r,17e,20e)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide (759 Da, Ligand)
- Hckcr2 (Complex from Hyphochytrium catenoides)
- Palmitic acid (256 Da, Ligand)
Cryo-EM structure of the potassium-selective channelrhodopsin HcKCR1 H225F mutant in lipid nanodisc
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8iu0
Q-score: 0.636
Tajima S, Kim YS, Fukuda M, Jo Y, Wang PY, Paggi JM, Inoue M, Byrne EFX, Kishi KE, Nakamura S, Ramakrishnan C, Takaramoto S, Nagata T, Konno M, Sugiura M, Katayama K, Matsui TE, Yamashita K, Kim S, Ikeda H, Kim J, Kandori H, Dror RO, Inoue K, Deisseroth K, Kato HE
Cell (2023) 186 pp. 4325-4344.e26 [ DOI: doi:10.1016/j.cell.2023.08.009 Pubmed: 37652010 ]
- Hckcr1 (31 kDa, Protein from Hyphochytrium catenoides)
- Hckcr1 (Complex from Hyphochytrium catenoides)
- Water (18 Da, Ligand)
- Retinal (284 Da, Ligand)
- (7r,17e,20e)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosa-17,20-dien-1-aminium 4-oxide (759 Da, Ligand)
- Palmitic acid (256 Da, Ligand)