Cryo-EM structure of the human TRPC1/C4 heteromer
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8wpl
Q-score: 0.504
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8wpm
Q-score: 0.442
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione (524 Da, Ligand)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8wpn
Q-score: 0.567
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Structure of a trp channel (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x6c
Q-score: 0.518
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ DOI: doi:10.1038/s41467-023-38281-3 Pubmed: 37137991 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8gvw
Q-score: 0.44
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ DOI: doi:10.1038/s41467-023-38281-3 Pubmed: 37137991 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8gvx
Q-score: 0.323
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ DOI: doi:10.1038/s41467-023-38281-3 Pubmed: 37137991 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7x6i
Q-score: 0.392
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ DOI: doi:10.1038/s41467-023-38281-3 Pubmed: 37137991 ]
- Trp channel (Complex from Homo sapiens)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Trp channel-g protein complex (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- G protein (Complex)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)