Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9cx3
Q-score: 0.423
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cx9
Q-score: 0.47
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8pm2
Q-score: 0.496
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG
bioRxiv (2023) [ DOI: doi:10.1101/2023.07.07.547762 Pubmed: 37461561 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- A complex of mouse trace-amine associated receptor 7f solubilized in lmng/chs bound to n,n-dimethylcyclohexylamine and coupled to: engineered guanine nucleotide-binding protein g(s) subunit alpha isoform short + guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 + guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 + nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 7f (41 kDa, Protein from Mus musculus)
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 7yon
Q-score: 0.572
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ DOI: doi:10.1016/j.str.2022.11.010 Pubmed: 36525977 ]
- Complex structure of pyy(3-36)-y2r-gi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuropeptide y receptor type 2 (43 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Peptide yy(3-36) (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Pyy(3-36) (Complex)
- Single-chain antibody fv fragment (scfv16) (27 kDa, Protein from Mus musculus)
Complex structure of Neuropeptide Y Y2 receptor in complex with NPY and Gi
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7yoo
Q-score: 0.531
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ DOI: doi:10.1016/j.str.2022.11.010 Pubmed: 36525977 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuropeptide y receptor type 2 (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex structure of npy-y2r-gi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein (Complex from Mus musculus)
- Single-chain antibody fv fragment (scfv16) (27 kDa, Protein from Mus musculus)
- Scfv16 (Complex)
- Neuropeptide y (4 kDa, Protein from Homo sapiens)
- Npy (Complex)
Complex structure of Neuropeptide Y Y2 receptor in complex with NPY and Gi (Consensus map)
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ DOI: doi:10.1016/j.str.2022.11.010 Pubmed: 36525977 ]
- Guanine nucleotide-binding protein (Complex from Mus musculus)
- Npy (Complex)
- Complex structure of npy-y2r-gi-scfv16 (Complex from Homo sapiens)
- Scfv16 (Complex)
Complex structure of Neuropeptide Y Y2 receptor in complex with NPY and Gi (Focused map on NPY-Y2R)
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ DOI: doi:10.1016/j.str.2022.11.010 Pubmed: 36525977 ]
- Guanine nucleotide-binding protein (Complex from Mus musculus)
- Npy (Complex)
- Complex structure of npy-y2r-gi-scfv16 (Complex from Homo sapiens)
- Scfv16 (Complex)
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ Pubmed: 36525977 DOI: doi:10.1016/j.str.2022.11.010 ]
- Complex structure of npy-y2r-gi-scfv16 (Complex from Homo sapiens)
- Scfv16 (Complex)
- Npy (Complex)
- Guanine nucleotide-binding protein (Complex from Mus musculus)