Cryo-EM structure of the human TRPC1/C4 heteromer
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8wpl
Q-score: 0.504
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8wpm
Q-score: 0.442
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione (524 Da, Ligand)
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8wpn
Q-score: 0.567
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Structure of a trp channel (Complex from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x6c
Q-score: 0.518
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8gvw
Q-score: 0.44
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8gvx
Q-score: 0.323
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7x6i
Q-score: 0.392
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Zinc ion (65 Da, Ligand)
- Trp channel (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- G protein (Complex)
- Phosphatidylethanolamine (734 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trp channel-g protein complex (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7vgx
Q-score: 0.501
Park C, Kim J, Ko SB, Choi YK, Jeong H, Woo H, Kang H, Bang I, Kim SA, Yoon TY, Seok C, Im W, Choi HJ
Nat Commun (2022) 13 pp. 853- [ DOI: doi:10.1038/s41467-022-28510-6 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of neuropeptide y y1 receptor (npy1r) with its endogeneous peptide-agonist neuropeptide y (npy), g protein and g-protein stabilizing antibody fragement (scfv16) (160 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Neuropeptide y (Complex)
- Neuropeptide y (4 kDa, Protein from Homo sapiens)
- Nucleotide-free g-protein heterotrimer (Complex from Homo sapiens)
- Neuropeptide y receptor type 1 (46 kDa, Protein from Homo sapiens)
- Neuropeptide y y1 receptor (npy1r) (Complex from Homo sapiens)
- Single-chain antibody fv fragment (scfv16) (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Single-chain antibody fv fragment (scfv16) (Complex from Mus musculus)