Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8wpn
Q-score: 0.567
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Structure of a trp channel (Complex from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human P2X3 receptor-compound 26a complex
Kim GR, Kim S, Kim YO, Han X, Nagel J, Kim J, Song DI, Muller CE, Yoon MH, Jin MS, Kim YC
J Med Chem (2024) 67 pp. 14443-14465 [ Pubmed: 39102524 DOI: doi:10.1021/acs.jmedchem.4c01214 ]
- Human p2x3 receptor-compound 26a complex (Complex from Homo sapiens)
- P2x purinoceptor 3 (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-[2-cyclopropyl-7-[[(1~{r})-1-naphthalen-2-ylethyl]amino]-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl]piperazine-1-carboxamide (456 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8hti
Q-score: 0.583
Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ
Nat Commun (2023) 14 pp. 8105-8105 [ Pubmed: 38062020 DOI: doi:10.1038/s41467-023-43983-9 ]
- Octanoic acid (caprylic acid) (144 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Complex of consensus olfactory receptor or52c in complex with octanoic acid, g protein and nanobody 35 (nb35) (140 kDa, Complex from Homo sapiens)
- Consensus olfactory receptor or52c (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8pm2
Q-score: 0.496
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG
bioRxiv (2023) [ DOI: doi:10.1101/2023.07.07.547762 Pubmed: 37461561 ]
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- Trace amine-associated receptor 7f (41 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- A complex of mouse trace-amine associated receptor 7f solubilized in lmng/chs bound to n,n-dimethylcyclohexylamine and coupled to: engineered guanine nucleotide-binding protein g(s) subunit alpha isoform short + guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 + guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 + nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
Complex structure of Neuropeptide Y Y2 receptor in complex with PYY(3-36) and Gi
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 7yon
Q-score: 0.572
Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ
Structure (2023) 31 pp. 44-57.e6 [ Pubmed: 36525977 DOI: doi:10.1016/j.str.2022.11.010 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Pyy(3-36) (Complex)
- Neuropeptide y receptor type 2 (43 kDa, Protein from Homo sapiens)
- Peptide yy(3-36) (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex)
- Complex structure of pyy(3-36)-y2r-gi-scfv16 (Complex from Homo sapiens)
- Single-chain antibody fv fragment (scfv16) (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Water (18 Da, Ligand)