Cryo-EM structure of the human TRPC1/C4 heteromer
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8wpl
Q-score: 0.504
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8wpm
Q-score: 0.442
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione (524 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8wpn
Q-score: 0.567
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01408-1 Pubmed: 39478185 ]
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Structure of a trp channel (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of dimeric UBR5
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8p82
Q-score: 0.299
Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Slabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thoma NH, Ebert BL
Mol Cell (2023) 83 pp. 2753-2767.e10 [ DOI: doi:10.1016/j.molcel.2023.06.028 Pubmed: 37478846 ]
- E3 ubiquitin-protein ligase ubr5 (313 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dimer of ubr5 (Complex from Homo sapiens)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x6c
Q-score: 0.518
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8gvw
Q-score: 0.44
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8gvx
Q-score: 0.323
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7x6i
Q-score: 0.392
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- Trp channel (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trp channel-g protein complex (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- G protein (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Initial DNA-lesion (Cy5) binding by XPC and TFIIH
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ebs
Q-score: 0.274
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W
Nature (2023) 617 pp. 170-175 [ Pubmed: 37076618 DOI: doi:10.1038/s41586-023-05959-z ]
- Xeroderma pigmentosum, complementation group c, isoform cra_a (107 kDa, Protein from Homo sapiens)
- Dna (16 kDa, DNA from synthetic construct)
- General transcription and dna repair factor iih helicase subunit xpd (88 kDa, Protein from Homo sapiens)
- Centrin-2 (19 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Uv excision repair protein rad23 homolog b (44 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Tfiih basal transcription factor complex helicase xpb subunit (89 kDa, Protein from Homo sapiens)
- Dna (cy5) (16 kDa, DNA from synthetic construct)
- General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 4, p52 (52 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
- Bulky dna lesion recognition complex (580 kDa, Complex from Homo sapiens)
- General transcription factor iih subunit 2 (46 kDa, Protein from Homo sapiens)
XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (Cy5)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8ebt
Q-score: 0.304
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W
Nature (2023) 617 pp. 170-175 [ Pubmed: 37076618 DOI: doi:10.1038/s41586-023-05959-z ]
- General transcription factor iih subunit 4 (50 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 1 (49 kDa, Protein from Homo sapiens)
- General transcription and dna repair factor iih helicase subunit xpd (83 kDa, Protein from Homo sapiens)
- Protein dna complex (610 kDa, Complex from Homo sapiens)
- General transcription factor iih subunit 3 (31 kDa, Protein from Homo sapiens)
- Dna (cy5) (13 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- General transcription and dna repair factor iih helicase subunit xpb (69 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 2 (42 kDa, Protein from Homo sapiens)
- Dna repair protein complementing xp-c cells (31 kDa, Protein from Homo sapiens)
- Dna repair protein complementing xp-a cells (20 kDa, Protein from Homo sapiens)
- Dna (13 kDa, DNA from synthetic construct)
- Iron/sulfur cluster (351 Da, Ligand)
- General transcription factor iih subunit 5 (7 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Centrin-2 (8 kDa, Protein from Homo sapiens)