Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8uyf
Q-score: 0.56
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D
Sci Adv (2024) 10 pp. eadj7408-eadj7408 [ Pubmed: 38241364 DOI: doi:10.1126/sciadv.adj7408 ]
Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8uyh
Q-score: 0.548
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D
Sci Adv (2024) 10 pp. eadj7408-eadj7408 [ Pubmed: 38241364 DOI: doi:10.1126/sciadv.adj7408 ]
- Amp-pnp-bound pediculus humanus (ph) pink1 dodecamer (Complex from Pediculus humanus corporis)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Serine/threonine-protein kinase pink1, mitochondrial (53 kDa, Protein from Pediculus humanus corporis)
Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8uyi
Q-score: 0.504
Gan ZY, Callegari S, Nguyen TN, Kirk NS, Leis A, Lazarou M, Dewson G, Komander D
Sci Adv (2024) 10 pp. eadj7408-eadj7408 [ Pubmed: 38241364 DOI: doi:10.1126/sciadv.adj7408 ]
- Adp-bound and phosphorylated pediculus humanus (ph) pink1 dodecamer (Complex from Pediculus humanus corporis)
- Serine/threonine-protein kinase pink1, mitochondrial (53 kDa, Protein from Pediculus humanus corporis)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
CryoEM structure of MFRV-VILP bound to IGF1Rzip
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8tan
Q-score: 0.424
Chrudinova M, Kirk NS, Chuard A, Venugopal H, Zhang F, Lubos M, Gelfanov V, Panikova T, Zakova L, Cutone J, Mojares M, DiMarchi R, Jiracek J, Altindis E
Mol Metab (2024) 80 pp. 101863-101863 [ DOI: doi:10.1016/j.molmet.2023.101863 Pubmed: 38182007 ]
- Igf1rzip (Complex from Homo sapiens)
- Insulin-like growth factor (6 kDa, Protein from Mandarin fish ranavirus)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1:2 complex of mfrv-vilp bound to igf1rzip (Complex)
- Mfrv-vilp (Complex from Mandarin fish ranavirus)
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u23
Q-score: 0.188
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinova M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
Nat Commun (2022) 13 pp. 6700-6700 [ Pubmed: 36335114 DOI: doi:10.1038/s41467-022-34391-6 ]
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Resolution: 5.03 Å
EM Method: Single-particle
Fitted PDBs: 7u6d
Q-score: 0.133
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martinez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC
Nat Commun (2022) 13 pp. 5695- [ DOI: doi:10.1038/s41467-022-33315-8 Pubmed: 36171189 ]
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7u6e
Q-score: 0.48
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martinez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC
Nat Commun (2022) 13 pp. 5695- [ DOI: doi:10.1038/s41467-022-33315-8 Pubmed: 36171189 ]
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Complex of im462 with insulin and fv 83-7 bound to insulin receptor, delta beta, leucine zippered form (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Im462 (2 kDa, Protein from synthetic construct)
- Isoform short of insulin receptor (106 kDa, Protein from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7s0q
Q-score: 0.328
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- Beta-d-mannopyranose (180 Da, Ligand)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7s8v
Q-score: 0.232
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ DOI: doi:10.1016/j.str.2022.05.007 Pubmed: 35660159 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwg
Q-score: 0.453
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ Pubmed: 32459985 DOI: doi:10.1016/j.str.2020.05.002 ]
- Insulin-like growth factor ii (Complex)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Head region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)