Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7u23
Q-score: 0.188
Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinova M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Ronald Kahn C
Nat Commun (2022) 13 pp. 6700-6700 [ DOI: doi:10.1038/s41467-022-34391-6 Pubmed: 36335114 ]
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Resolution: 5.03 Å
EM Method: Single-particle
Fitted PDBs: 7u6d
Q-score: 0.133
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martinez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC
Nat Commun (2022) 13 pp. 5695- [ Pubmed: 36171189 DOI: doi:10.1038/s41467-022-33315-8 ]
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7u6e
Q-score: 0.48
Kirk NS, Chen Q, Wu YG, Asante AL, Hu H, Espinosa JF, Martinez-Olid F, Margetts MB, Mohammed FA, Kiselyov VV, Barrett DG, Lawrence MC
Nat Commun (2022) 13 pp. 5695- [ Pubmed: 36171189 DOI: doi:10.1038/s41467-022-33315-8 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Isoform short of insulin receptor (106 kDa, Protein from Homo sapiens)
- Complex of im462 with insulin and fv 83-7 bound to insulin receptor, delta beta, leucine zippered form (Complex from Homo sapiens)
- Im462 (2 kDa, Protein from synthetic construct)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7s0q
Q-score: 0.328
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ Pubmed: 35660159 DOI: doi:10.1016/j.str.2022.05.007 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor i (7 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7s8v
Q-score: 0.232
Xu Y, Margetts MB, Venugopal H, Menting JG, Kirk NS, Croll TI, Delaine C, Forbes BE, Lawrence MC
Structure (2022) 30 pp. 1098-1108.e6 [ Pubmed: 35660159 DOI: doi:10.1016/j.str.2022.05.007 ]
- A complex of igf-i with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor (250 MDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (108 kDa, Protein from Homo sapiens)
- Insulin receptor (109 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwg
Q-score: 0.453
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 6vwh
Q-score: 0.207
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vwi
Q-score: 0.407
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Insulin-like growth factor ii (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Head region of the close-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii. (250 kDa, Complex from Homo sapiens)
- Insulin-like growth factor 1 receptor (Complex from Homo sapiens)
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Resolution: 4.21 Å
EM Method: Single-particle
Fitted PDBs: 6vwj
Q-score: 0.245
Xu Y, Kirk NS, Venugopal H, Margetts MB, Croll TI, Sandow JJ, Webb AI, Delaine CA, Forbes BE, Lawrence MC
Structure (2020) 28 pp. 786-798.e6 [ DOI: doi:10.1016/j.str.2020.05.002 Pubmed: 32459985 ]
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (108 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Leg region of the open-leg conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor ii (250 kDa, Complex from Homo sapiens)