High-resolution cryo-EM structure of the human 80S ribosome - (composite structure)
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature (2017) 551 pp. 472-477 [ Pubmed: 29143818 DOI: doi:10.1038/nature24482 ]
- 60s ribosomal protein l4 (47 kDa, Protein from Human)
- 40s ribosomal protein s7 (22 kDa, Protein from Human)
- 60s ribosomal protein l11 (20 kDa, Protein from Human)
- 60s ribosomal protein l21 (18 kDa, Protein from Human)
- 60s ribosomal protein l32 (15 kDa, Protein from Human)
- 40s ribosomal protein s11 (18 kDa, Protein from Human)
- 40s ribosomal protein s3 (26 kDa, Protein from Human)
- 40s ribosomal protein s9 (22 kDa, Protein from Human)
- 60s ribosomal protein l39 (6 kDa, Protein from Human)
- 60s ribosomal protein l37a (10 kDa, Protein from Human)
- 60s ribosomal protein l26 (17 kDa, Protein from Human)
- 60s ribosomal protein l29 (17 kDa, Protein from Human)
- 40s ribosomal protein s12 (14 kDa, Protein from Human)
- 60s ribosomal protein l3 (46 kDa, Protein from Human)
- 40s ribosomal protein s25 (13 kDa, Protein from Human)
- 40s ribosomal protein sa (32 kDa, Protein from Human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Human)
- 40s ribosomal protein s29 (6 kDa, Protein from Human)
- 40s ribosomal protein s15a (14 kDa, Protein from Human)
- 40s ribosomal protein s24 (15 kDa, Protein from Human)
- 40s ribosomal protein s26 (13 kDa, Protein from Human)
- 40s ribosomal protein s20 (13 kDa, Protein from Human)
- 40s ribosomal protein s5 (22 kDa, Protein from Human)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Human)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l36a (12 kDa, Protein from Human)
- 60s ribosomal protein l6 (32 kDa, Protein from Human)
- 60s ribosomal protein l37 (11 kDa, Protein from Human)
- 60s ribosomal protein l22 (14 kDa, Protein from Human)
- 40s ribosomal protein s14 (16 kDa, Protein from Human)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Human)
- Hygromycin b (527 Da, Ligand)
- 40s ribosomal protein s21 (9 kDa, Protein from Human)
- 40s ribosomal protein s17 (15 kDa, Protein from Human)
- 40s ribosomal protein s6 (28 kDa, Protein from Human)
- 60s ribosomal protein l7a (30 kDa, Protein from Human)
- 18s ribosomal rna (603 kDa, RNA from Human)
- 60s ribosomal protein l30 (12 kDa, Protein from Human)
- 60s ribosomal protein l7 (29 kDa, Protein from Human)
- 60s ribosomal protein l27a (16 kDa, Protein from Human)
- 40s ribosomal protein s19 (16 kDa, Protein from Human)
- 40s ribosomal protein s3a (30 kDa, Protein from Human)
- 5s ribosomal rna (38 kDa, RNA from Human)
- 40s ribosomal protein s18 (17 kDa, Protein from Human)
- 60s ribosomal protein l14 (23 kDa, Protein from Human)
- 60s ribosomal protein l10-like (24 kDa, Protein from Human)
- 60s ribosomal protein l13 (24 kDa, Protein from Human)
- 60s ribosomal protein l35 (14 kDa, Protein from Human)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Human)
- 40s ribosomal protein s28 (7 kDa, Protein from Human)
- 60s ribosomal protein l19 (23 kDa, Protein from Human)
- 60s ribosomal protein l38 (8 kDa, Protein from Human)
- 40s ribosomal protein s30 (6 kDa, Protein from Human)
- 80s ribosome with ligand hht and hyg (4 MDa, Complex from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Human)
- 60s ribosomal protein l17 (21 kDa, Protein from Human)
- 60s ribosomal protein l13a (23 kDa, Protein from Human)
- 60s ribosomal protein l28 (15 kDa, Protein from Human)
- 60s ribosomal protein l9 (21 kDa, Protein from Human)
- 60s ribosomal protein l24 (17 kDa, Protein from Human)
- 60s ribosomal protein l31 (14 kDa, Protein from Human)
- 5.8s ribosomal rna (50 kDa, RNA from Human)
- 60s ribosomal protein l27 (15 kDa, Protein from Human)
- 40s ribosomal protein s8 (24 kDa, Protein from Human)
- 60s ribosomal protein l18 (21 kDa, Protein from Human)
- Human initiator met-trna-i (24 kDa, RNA from Human)
- 60s ribosomal protein l15 (24 kDa, Protein from Human)
- 60s ribosomal protein l10a (24 kDa, Protein from Human)
- 60s ribosomal protein l8 (28 kDa, Protein from Human)
- 60s ribosomal protein l36 (12 kDa, Protein from Human)
- 40s ribosomal protein s13 (17 kDa, Protein from Human)
- 40s ribosomal protein s23 (15 kDa, Protein from Human)
- 60s ribosomal protein l35a (12 kDa, Protein from Human)
- 60s ribosomal protein l23a (17 kDa, Protein from Human)
- Water (18 Da, Ligand)
- 28s ribosomal rna (1 MDa, RNA from Human)
- 40s ribosomal protein s10 (18 kDa, Protein from Human)
- 40s ribosomal protein s16 (16 kDa, Protein from Human)
- 60s ribosomal protein l34 (13 kDa, Protein from Human)
- 60s ribosomal protein l41 (3 kDa, Protein from Human)
- 40s ribosomal protein s27 (9 kDa, Protein from Human)
- 60s ribosomal protein l18a (20 kDa, Protein from Human)
- 40s ribosomal protein s2 (31 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l5 (34 kDa, Protein from Human)
- 60s ribosomal protein l23 (14 kDa, Protein from Human)
- (3beta)-o~3~-[(2r)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine (545 Da, Ligand)
High-resolution cryo-EM structure of the human 80S ribosome
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature (2017) 551 pp. 472-477 [ Pubmed: 29143818 DOI: doi:10.1038/nature24482 ]
- 80s ribosome (4 MDa, Complex from Homo sapiens)
High-resolution cryo-EM structure of the human 80S ribosome
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature (2017) 551 pp. 472-477 [ Pubmed: 29143818 DOI: doi:10.1038/nature24482 ]
- 80s ribosome with ligand hht and hyg (4 MDa, Complex from Homo sapiens)
High-resolution cryo-EM structure of the human 80S ribosome
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature (2017) 551 pp. 472-477 [ Pubmed: 29143818 DOI: doi:10.1038/nature24482 ]
- 80s ribosome with ligand hht and hyg (4 MDa, Complex from Homo sapiens)
High-resolution cryo-EM structure of the human 80S ribosome
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature (2017) 551 pp. 472-477 [ Pubmed: 29143818 DOI: doi:10.1038/nature24482 ]
- 80s ribosome with ligand hht and hyg (4 MDa, Complex from Homo sapiens)
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5lks
Q-score: 0.429
Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP
Nat Commun (2016) 7 pp. 12856-12856 [ Pubmed: 27665925 DOI: doi:10.1038/ncomms12856 ]
- 40s ribosomal protein s9 (22 kDa, Protein from Human)
- 40s ribosomal protein s7 (22 kDa, Protein from Human)
- 60s ribosomal protein l11 (20 kDa, Protein from Human)
- 60s ribosomal protein l21 (18 kDa, Protein from Human)
- 60s ribosomal protein l32 (15 kDa, Protein from Human)
- 60s ribosomal protein l4 (47 kDa, Protein from Human)
- 40s ribosomal protein s3 (26 kDa, Protein from Human)
- 60s ribosomal protein l14 (23 kDa, Protein from Human)
- 40s ribosomal protein s11 (18 kDa, Protein from Human)
- 60s ribosomal protein l19 (23 kDa, Protein from Human)
- 40s ribosomal protein s20 (13 kDa, Protein from Human)
- 60s ribosomal protein l39 (6 kDa, Protein from Human)
- 60s ribosomal protein l37a (10 kDa, Protein from Human)
- 60s ribosomal protein l26 (17 kDa, Protein from Human)
- 18s ribosomal rna (602 kDa, RNA from Human)
- 40s ribosomal protein s12 (14 kDa, Protein from Human)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Human)
- 60s ribosomal protein l3 (46 kDa, Protein from Human)
- 40s ribosomal protein s25 (13 kDa, Protein from Human)
- 40s ribosomal protein sa (32 kDa, Protein from Human)
- 40s ribosomal protein s29 (6 kDa, Protein from Human)
- 60s ribosomal protein l10a (24 kDa, Protein from Human)
- 40s ribosomal protein s15 (17 kDa, Protein from Human)
- 40s ribosomal protein s24 (15 kDa, Protein from Human)
- 60s ribosomal protein l5 (34 kDa, Protein from Human)
- 40s ribosomal protein s5 (22 kDa, Protein from Human)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l6 (32 kDa, Protein from Human)
- 40s ribosomal protein s21 (9 kDa, Protein from Human)
- 60s ribosomal protein l36a (12 kDa, Protein from Human)
- 60s ribosomal protein l10-like (24 kDa, Protein from Human)
- 40s ribosomal protein s14 (16 kDa, Protein from Human)
- 5s ribosomal rna (38 kDa, RNA from Human)
- Ribosomal protein l29, isoform cra_a (17 kDa, Protein from Human)
- 28s ribosomal rna (1 MDa, RNA from Human)
- 60s ribosomal protein l30 (12 kDa, Protein from Human)
- 60s ribosomal protein l7 (29 kDa, Protein from Human)
- 60s ribosomal protein l27 (15 kDa, Protein from Human)
- 5.8s ribosomal rna (50 kDa, RNA from Human)
- 60s ribosomal protein l27a (16 kDa, Protein from Human)
- 4-{(2r)-2-[(1s,3s,5s)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione (281 Da, Ligand)
- 40s ribosomal protein s19 (16 kDa, Protein from Human)
- 40s ribosomal protein s3a (30 kDa, Protein from Human)
- 60s ribosomal protein l13 (24 kDa, Protein from Human)
- 60s ribosomal protein l35 (14 kDa, Protein from Human)
- 60s ribosomal protein l37 (11 kDa, Protein from Human)
- 40s ribosomal protein s8 (24 kDa, Protein from Human)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Human)
- 40s ribosomal protein s28 (7 kDa, Protein from Human)
- 60s ribosomal protein l38 (8 kDa, Protein from Human)
- 60s ribosomal protein l28 (15 kDa, Protein from Human)
- 40s ribosomal protein s15a (14 kDa, Protein from Human)
- 60s ribosomal protein l22 (14 kDa, Protein from Human)
- 60s ribosomal protein l13a (23 kDa, Protein from Human)
- 40s ribosomal protein s26 (13 kDa, Protein from Human)
- 60s ribosomal protein l31 (14 kDa, Protein from Human)
- 60s ribosomal protein l9 (21 kDa, Protein from Human)
- 60s ribosomal protein l24 (17 kDa, Protein from Human)
- 40s ribosomal protein s6 (28 kDa, Protein from Human)
- Ribosomal protein s30 (14 kDa, Protein from Human)
- 60s ribosomal protein l18 (21 kDa, Protein from Human)
- 60s ribosomal protein l15 (24 kDa, Protein from Human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Human)
- 60s ribosomal protein l23a (17 kDa, Protein from Human)
- 60s ribosomal protein l8 (28 kDa, Protein from Human)
- 60s ribosomal protein l36 (12 kDa, Protein from Human)
- 40s ribosomal protein s13 (17 kDa, Protein from Human)
- 60s ribosomal protein l35a (12 kDa, Protein from Human)
- Water (18 Da, Ligand)
- 60s ribosomal protein l18a (20 kDa, Protein from Human)
- 40s ribosomal protein s18 (17 kDa, Protein from Human)
- 40s ribosomal protein s23 (15 kDa, Protein from Human)
- 60s ribosomal protein l17 (21 kDa, Protein from Human)
- 40s ribosomal protein s10 (18 kDa, Protein from Human)
- 40s ribosomal protein s16 (16 kDa, Protein from Human)
- 60s ribosomal protein l7a (30 kDa, Protein from Human)
- 60s ribosomal protein l34 (13 kDa, Protein from Human)
- 60s ribosomal protein l41 (3 kDa, Protein from Human)
- 40s ribosomal protein s27 (9 kDa, Protein from Human)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Human)
- 40s ribosomal protein s17 (15 kDa, Protein from Human)
- 40s ribosomal protein s2 (31 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l23 (14 kDa, Protein from Human)
- Human 80s ribsome (Complex from Homo sapiens)
Structure of the human 80S ribosome
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 4ug0
Q-score: 0.44
Khatter H, Myasnikov AG, Natchiar SK, Klaholz BP
Nature (2015) 520 pp. 640-645 [ DOI: doi:10.1038/nature14427 Pubmed: 25901680 ]
- Hela cytoplasmic 80s (4 MDa, Complex from Homo sapiens)
- 80s human (4 MDa, Sample)
Cryo-EM structure of prokaryotic 30S Translation Initiation Complex.
Simonetti A, Marzi S, Myasnikov AG, Fabbretti A, Yusupov M, Gualerzi CO, Klaholz BP
Nature (2008) 455 pp. 416-420 [ DOI: doi:10.1038/nature07192 Pubmed: 18758445 ]
- 30s (850 kDa, Complex from Thermus thermophilus HB8)
- Translation initiation factor if2 (63 kDa, Protein from Thermus thermophilus HB8)
- Translation initiation factor if1 (8 kDa, Protein from Thermus thermophilus HB8)
- Prokaryotic 30s translation initiation complex. t. thermophilus 30s ribosomal subunit complexed with t. thermophilus if1, t. thermophilus if2, e. coli fmet-trna and mk27 mrna. (900 kDa, Sample)
- Messanger rna (8 kDa, RNA from Escherichia coli)
- Fmet-trnafmet (25 kDa, RNA from Escherichia coli)
Visualization of release factor 3 on the ribosome during termination of protein synthesis.
Klaholz BP, Myasnikov AG, Van Heel M
Nature (2004) 427 pp. 862-865 [ DOI: doi:10.1038/nature02332 Pubmed: 14985767 ]
- 70s - rf3 complex e.coli (2 MDa, Sample)
- 70s (Complex)
- Isoleucin transfer rna (RNA from Escherichia coli)
- Messenger rna (RNA from Escherichia coli)
- Release factor 3 (Protein from Escherichia coli)
Visualization of release factor 3 on the ribosome during termination of protein synthesis.
Klaholz BP, Myasnikov AG, Van Heel M
Nature (2004) 427 pp. 862-865 [ DOI: doi:10.1038/nature02332 Pubmed: 14985767 ]
- 70s (Complex)
- Isoleucin transfer rna (RNA from Escherichia coli)
- 70s - rf3 complex e.coli (2 MDa, Sample)
- Messenger rna (RNA from Escherichia coli)
- Release factor 3 (Protein from Escherichia coli)