Cryo-EM structure of FLVCR2 in the inward-facing state with choline bound
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8vzn
Q-score: 0.583
Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F
Nature (2024) 629 pp. 704-709 [ Pubmed: 38693257 DOI: doi:10.1038/s41586-024-07326-y ]
- Flvcr2 in the inward-facing state complexed with choline and fab flv9 (110 kDa, Complex from Mus musculus)
- Fab flv9 light chain (23 kDa, Protein from synthetic construct)
- Choline ion (104 Da, Ligand)
- Fab flv9 heavy chain (25 kDa, Protein from synthetic construct)
- Feline leukemia virus subgroup c cellular receptor 2 (60 kDa, Protein from Mus musculus)
Cryo-EM structure of FLVCR2 in the outward-facing state with choline bound
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8vzo
Q-score: 0.637
Cater RJ, Mukherjee D, Gil-Iturbe E, Erramilli SK, Chen T, Koo K, Santander N, Reckers A, Kloss B, Gawda T, Choy BC, Zhang Z, Katewa A, Larpthaveesarp A, Huang EJ, Mooney SWJ, Clarke OB, Yee SW, Giacomini KM, Kossiakoff AA, Quick M, Arnold T, Mancia F
Nature (2024) 629 pp. 704-709 [ Pubmed: 38693257 DOI: doi:10.1038/s41586-024-07326-y ]
- Fab flv23 heavy chain (25 kDa, Protein from synthetic construct)
- Flvcr2 in the outward-facing state complexed with choline and fab flv23 (110 kDa, Complex from Mus musculus)
- Fab flv23 light chain (23 kDa, Protein from synthetic construct)
- Choline ion (104 Da, Ligand)
- Feline leukemia virus subgroup c cellular receptor 2 (60 kDa, Protein from Mus musculus)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8pg0
Q-score: 0.528
Ciuta AD, Nosol K, Kowal J, Mukherjee S, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun (2023) 14 pp. 5774-5774 [ DOI: doi:10.1038/s41467-023-41552-8 Pubmed: 37723174 ]
- Bicarbonate ion (61 Da, Ligand)
- Solute carrier organic anion transporter family member 1b3 (77 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Fab19 (light chain, variable region) (23 kDa, Protein from Homo sapiens)
- Human oatp1b3 (180 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab19 (heavy chain, variable region) (25 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8phw
Q-score: 0.38
Ciuta AD, Nosol K, Kowal J, Mukherjee S, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun (2023) 14 pp. 5774-5774 [ DOI: doi:10.1038/s41467-023-41552-8 Pubmed: 37723174 ]
- Human oatp1b1 (180 kDa, Complex)
- Solute carrier organic anion transporter family member 1b1 (76 kDa, Protein from Homo sapiens)
- Fab18 (light chain, variable region) (23 kDa, Protein from Homo sapiens)
- Solute carrier organic anion transporter family member 1b1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Fab18 (variable region) (Complex from Homo sapiens)
- Fab18 (heavy chain, variable region) (24 kDa, Protein from Homo sapiens)
- Estrone 3-sulfate (350 Da, Ligand)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6bf8
Q-score: 0.153
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6bf6
Q-score: 0.162
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6bf7
Q-score: 0.16
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 7.2 Å
EM Method: Single-particle
Fitted PDBs: 6bf9
Q-score: 0.156
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6b7z
Q-score: 0.146
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Fab h11 heavy chain (23 kDa, Protein from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Fab h11 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6b70
Q-score: 0.374
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin (11 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme/insulin (100 kDa, Complex from Homo sapiens)
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)