Cryo-EM structure of human NTCP-Bulevirtide complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8rqf
Q-score: 0.492
Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sorensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP
Nat Commun (2024) 15 pp. 2476-2476 [ DOI: doi:10.1038/s41467-024-46706-w Pubmed: 38509088 ]
- Heavy chain of fab3 (25 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Polymerase (5 kDa, Protein from hepatitis B virus genotype C)
- Fab-specific nanobody (13 kDa, Protein from Lama glama)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- N-tetradecanoylglycine (285 Da, Ligand)
- Light chain of fab3 (23 kDa, Protein from Homo sapiens)
- Structure of bulevirtide-bound human ntcp in complex with fab and nanobody (110 kDa, Complex from Homo sapiens)
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7zyi
Q-score: 0.502
Liu H, Irobalieva RN, Bang-Sorensen R, Nosol K, Mukherjee S, Agrawal P, Stieger B, Kossiakoff AA, Locher KP
Cell Res (2022) 32 pp. 773-776 [ Pubmed: 35726088 DOI: doi:10.1038/s41422-022-00680-4 ]
- Glycochenodeoxycholic acid (449 Da, Ligand)
- Heavy chain of fab (25 kDa, Protein from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Light chain of fab (23 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Sodium/bile acid cotransporter (ntcp) in complex with fab and nanobody (110 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nanobody (13 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6ur8
Q-score: 0.448
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun (2020) 11 pp. 1598-1598 [ Pubmed: 32221310 DOI: doi:10.1038/s41467-020-15363-0 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Varenicline (211 Da, Ligand)
- Chimera of soluble cytochrome b562 (bril) and neuronal acetylcholine receptor subunit alpha-4 (56 kDa, Protein from Homo sapiens)
- Human alpha4beta2 nicotinic acetylcholine receptor in complex fab fragments and bound to varenicline (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (45 kDa, Protein from Homo sapiens)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6usf
Q-score: 0.394
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun (2020) 11 pp. 1598-1598 [ Pubmed: 32221310 DOI: doi:10.1038/s41467-020-15363-0 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab light chain (23 kDa, Protein from Homo sapiens)
- Fab heavy chain (24 kDa, Protein from Homo sapiens)
- Varenicline (211 Da, Ligand)
- Chimera of soluble cytochrome b562 (bril) and neuronal acetylcholine receptor subunit alpha-4 (55 kDa, Protein from Homo sapiens)
- Human alpha4beta2 nicotinic acetylcholine receptor in complex fab fragments and bound to varenicline (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6bf8
Q-score: 0.153
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6bf6
Q-score: 0.162
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6bf7
Q-score: 0.16
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)
Resolution: 7.2 Å
EM Method: Single-particle
Fitted PDBs: 6bf9
Q-score: 0.156
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6b7z
Q-score: 0.146
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Fab h11 light chain (23 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Fab h11 heavy chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6b70
Q-score: 0.374
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin degrading enzyme/insulin (100 kDa, Complex from Homo sapiens)
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin (11 kDa, Protein from Homo sapiens)
- Fab h11-e heavy chain (23 kDa, Protein from Homo sapiens)
- Fab h11-e light chain (23 kDa, Protein from Homo sapiens)