Cryo-EM structure of human NTCP-Bulevirtide complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8rqf
Q-score: 0.492
Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sorensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP
Nat Commun (2024) 15 pp. 2476-2476 [ DOI: doi:10.1038/s41467-024-46706-w Pubmed: 38509088 ]
- Structure of bulevirtide-bound human ntcp in complex with fab and nanobody (110 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Light chain of fab3 (23 kDa, Protein from Homo sapiens)
- Heavy chain of fab3 (25 kDa, Protein from Homo sapiens)
- Polymerase (5 kDa, Protein from hepatitis B virus genotype C)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab-specific nanobody (13 kDa, Protein from Lama glama)
- N-tetradecanoylglycine (285 Da, Ligand)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin (Complex from Bos taurus)
- Sangivamycin (309 Da, Ligand)
Rhodopsin kinase (GRK1) in complex with rhodopsin
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Retinal (284 Da, Ligand)
- Rhodopsin kinase (grk1) in complex with rhodopsin (Complex from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Sangivamycin (309 Da, Ligand)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Rhodopsin kinase, rhodopsin (Complex from Bos taurus)
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin stabilized by fab1 (Complex)
- Fab1 light chain (23 kDa, Protein from Homo sapiens)
- Fab1 heavy chain (24 kDa, Protein from Homo sapiens)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Fab heavy and light chains (Complex from Homo sapiens)
- Sangivamycin (309 Da, Ligand)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Rhodopsin kinase, rhodopsin (Complex from Bos taurus)
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin stabilized by fab6 (Complex)
- Fab6 light chain (23 kDa, Protein from Homo sapiens)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Fab6 heavy chain (25 kDa, Protein from Homo sapiens)
- Fab6 heavy and light chains (Complex from Homo sapiens)
- Sangivamycin (309 Da, Ligand)