Human Vault Cage in complex with PARP4 and NAD+
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.27.601040 Pubmed: 38979142 ]
- Major vault protein (99 kDa, Protein from Homo sapiens)
- Ternary complex of nad+ and human parp4 bound to oligomerized human mvp (12 MDa, Complex from Homo sapiens)
- Protein mono-adp-ribosyltransferase parp4 (192 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
Cryo-EM structure of human NTCP-Bulevirtide complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8rqf
Q-score: 0.492
Liu H, Zakrzewicz D, Nosol K, Irobalieva RN, Mukherjee S, Bang-Sorensen R, Goldmann N, Kunz S, Rossi L, Kossiakoff AA, Urban S, Glebe D, Geyer J, Locher KP
Nat Commun (2024) 15 pp. 2476-2476 [ DOI: doi:10.1038/s41467-024-46706-w Pubmed: 38509088 ]
- Structure of bulevirtide-bound human ntcp in complex with fab and nanobody (110 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Light chain of fab3 (23 kDa, Protein from Homo sapiens)
- Heavy chain of fab3 (25 kDa, Protein from Homo sapiens)
- Polymerase (5 kDa, Protein from hepatitis B virus genotype C)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab-specific nanobody (13 kDa, Protein from Lama glama)
- N-tetradecanoylglycine (285 Da, Ligand)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8pg0
Q-score: 0.528
Ciuta AD, Nosol K, Kowal J, Mukherjee S, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun (2023) 14 pp. 5774-5774 [ DOI: doi:10.1038/s41467-023-41552-8 Pubmed: 37723174 ]
- Bicarbonate ion (61 Da, Ligand)
- Solute carrier organic anion transporter family member 1b3 (77 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Fab19 (light chain, variable region) (23 kDa, Protein from Homo sapiens)
- Human oatp1b3 (180 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab19 (heavy chain, variable region) (25 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8phw
Q-score: 0.38
Ciuta AD, Nosol K, Kowal J, Mukherjee S, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun (2023) 14 pp. 5774-5774 [ DOI: doi:10.1038/s41467-023-41552-8 Pubmed: 37723174 ]
- Human oatp1b1 (180 kDa, Complex)
- Solute carrier organic anion transporter family member 1b1 (76 kDa, Protein from Homo sapiens)
- Fab18 (light chain, variable region) (23 kDa, Protein from Homo sapiens)
- Solute carrier organic anion transporter family member 1b1 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Fab18 (variable region) (Complex from Homo sapiens)
- Fab18 (heavy chain, variable region) (24 kDa, Protein from Homo sapiens)
- Estrone 3-sulfate (350 Da, Ligand)
LRRC8A:C conformation 2 (oblong) top mask
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8dr8
Q-score: 0.463
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 2 (oblong)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8dre
Q-score: 0.382
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 1 (round) top focus
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8drk
Q-score: 0.47
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C conformation 1 (round)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8ds3
Q-score: 0.327
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c (620 kDa, Complex from Mus musculus)
LRRC8A:C in MSPE3D1 nanodisc top focus
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8ds9
Q-score: 0.39
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c channel (620 kDa, Complex from Mus musculus)
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8dsa
Q-score: 0.326
Kern DM, Bleier J, Mukherjee S, Hill JM, Kossiakoff AA, Isacoff EY, Brohawn SG
Nat Struct Mol Biol (2023) 30 pp. 841-852 [ Pubmed: 36928458 DOI: doi:10.1038/s41594-023-00944-6 ]
- Water (18 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8c (93 kDa, Protein from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Volume-regulated anion channel subunit lrrc8a,soluble cytochrome b562 (105 kDa, Protein from Mus musculus)
- Lrrc8a:c channel (620 kDa, Complex from Mus musculus)