Xenopus laevis hyaluronan synthase 1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8smm
Q-score: 0.504
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Fab15 light chain (23 kDa, Protein from Homo sapiens)
- Fab15 heavy chain (24 kDa, Protein from Homo sapiens)
- Hyaluronan synthase 1 (70 kDa, Protein from Xenopus laevis)
- Xenopus laevis hyaluronan synthase 1 in complex with a fab molecule (118 kDa, Complex from Xenopus laevis)
Xenopus laevis hyaluronan synthase 1, nascent HA polymer bound state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8smn
Q-score: 0.557
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Water (18 Da, Ligand)
- Fab15 light chain (23 kDa, Protein from Homo sapiens)
- Fab15 heavy chain (24 kDa, Protein from Homo sapiens)
- Hyaluronan synthase 1 (70 kDa, Protein from Xenopus laevis)
- Xenopus laevis hyaluronan synthase 1 in complex with a fab molecule, nascent ha polymer bound state (118 kDa, Complex from Xenopus laevis)
Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8smp
Q-score: 0.511
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Fab15 light chain (23 kDa, Protein from Homo sapiens)
- Fab15 heavy chain (24 kDa, Protein from Homo sapiens)
- Hyaluronan synthase 1 (70 kDa, Protein from Xenopus laevis)
- Xenopus laevis hyaluronan synthase 1, udp-bound, gating loop inserted state (118 kDa, Complex from Xenopus laevis)
Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8snc
Q-score: 0.509
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Ternary complex of chlorella virus hyaluronan synthase bound to nanobodies 872 and 886 (95 MDa, Complex from Paramecium bursaria Chlorella virus 1)
- Water (18 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Hyaluronan synthase (65 kDa, Protein from Paramecium bursaria Chlorella virus CZ-2)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nanobody 881 (15 kDa, Protein from Lama glama)
- Nanobody 872 (14 kDa, Protein from Lama glama)
Chlorella virus Hyaluronan Synthase bound to GlcNAc primer and UDP-GlcA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8snd
Q-score: 0.512
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Nanobody 881 (15 kDa, Protein from Lama glama)
- Uridine-5'-diphosphate-glucuronic acid (580 Da, Ligand)
- Water (18 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Hyaluronan synthase (65 kDa, Protein from Paramecium bursaria Chlorella virus CZ-2)
- Nanobody 872 (14 kDa, Protein from Lama glama)
- Ternary complex of chlorella virus hyaluronan synthase bound to nanobodies 872 and 881 (97 MDa, Complex from Paramecium bursaria Chlorella virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Chlorella virus Hyaluronan Synthase bound to GlcA extended GlcNAc primer and UDP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8sne
Q-score: 0.546
Gorniak I, Stephens Z, Erramilli SK, Gawda T, Kossiakoff AA, Zimmer J
Nat Struct Mol Biol (2025) 32 pp. 161-171 [ Pubmed: 39322765 DOI: doi:10.1038/s41594-024-01389-1 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Ternary complex of chlorella virus hyaluronan synthase bound to nanobodies 872 and 886 (95 MDa, Complex from Paramecium bursaria Chlorella virus 1)
- Manganese (ii) ion (54 Da, Ligand)
- Hyaluronan synthase (65 kDa, Protein from Paramecium bursaria Chlorella virus CZ-2)
- Nanobody 886 (14 kDa, Protein from Lama glama)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Nanobody 872 (14 kDa, Protein from Lama glama)
Cryo-EM structure of the HIV-1 restriction factor human SERINC3
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7ru6
Q-score: 0.323
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ DOI: doi:10.1038/s41467-023-39262-2 Pubmed: 37474505 ]
- Sia (25 kDa, Protein from synthetic construct)
- Hserinc3-sia (55 kDa, Complex from Homo sapiens)
- Serine incorporator 3 (55 kDa, Protein from Homo sapiens)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7rug
Q-score: 0.244
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ DOI: doi:10.1038/s41467-023-39262-2 Pubmed: 37474505 ]
- Hserinc3-deltaicl4-sia (52 kDa, Complex from Homo sapiens)
- Sia (25 kDa, Protein from synthetic construct)
- Serine incorporator 3 (52 kDa, Protein from Homo sapiens)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin (Complex from Bos taurus)
- Sangivamycin (309 Da, Ligand)
Rhodopsin kinase (GRK1) in complex with rhodopsin
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Retinal (284 Da, Ligand)
- Rhodopsin kinase (grk1) in complex with rhodopsin (Complex from Bos taurus)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Sangivamycin (309 Da, Ligand)