Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
- Oligomerized human mvp (7 MDa, Complex from Homo sapiens)
- Major vault protein (99 kDa, Protein from Homo sapiens)
Human Vault Cage in complex with NAD+
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
Human Vault Cage in complex with PARP4
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
- Protein mono-adp-ribosyltransferase parp4 (192 kDa, Protein from Homo sapiens)
- Binary complex of human parp4 bound to oligomerized human mvp (12 MDa, Complex from Homo sapiens)
- Major vault protein (99 kDa, Protein from Homo sapiens)
Human Vault Cage in complex with PARP4 and NAD+
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Protein mono-adp-ribosyltransferase parp4 (192 kDa, Protein from Homo sapiens)
- Major vault protein (99 kDa, Protein from Homo sapiens)
- Ternary complex of nad+ and human parp4 bound to oligomerized human mvp (12 MDa, Complex from Homo sapiens)
Human Vault Cage in the presence of ADP
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
- Major vault protein (Protein from Homo sapiens)
- Oligomerized human mvp in the presence of adp (7 MDa, Complex from Homo sapiens)
Human Vault Cage in complex with the MINT domain of PARP4
Lodwick JE, Shen R, Erramilli S, Xie Y, Roganowicz K, Kossiakoff AA, Zhao M
bioRxiv (2024) [ Pubmed: 38979142 DOI: doi:10.1101/2024.06.27.601040 ]
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8phw
Q-score: 0.38
Ciuta AD, Nosol K, Kowal J, Mukherjee S, Ramirez AS, Stieger B, Kossiakoff AA, Locher KP
Nat Commun (2023) 14 pp. 5774-5774 [ Pubmed: 37723174 DOI: doi:10.1038/s41467-023-41552-8 ]
- Fab18 (light chain, variable region) (23 kDa, Protein from Homo sapiens)
- Fab18 (heavy chain, variable region) (24 kDa, Protein from Homo sapiens)
- Solute carrier organic anion transporter family member 1b1 (Complex from Homo sapiens)
- Fab18 (variable region) (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Estrone 3-sulfate (350 Da, Ligand)
- Human oatp1b1 (180 kDa, Complex)
- Solute carrier organic anion transporter family member 1b1 (76 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HIV-1 restriction factor human SERINC3
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7ru6
Q-score: 0.323
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ Pubmed: 37474505 DOI: doi:10.1038/s41467-023-39262-2 ]
- Serine incorporator 3 (55 kDa, Protein from Homo sapiens)
- Sia (25 kDa, Protein from synthetic construct)
- Hserinc3-sia (55 kDa, Complex from Homo sapiens)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7rug
Q-score: 0.244
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ Pubmed: 37474505 DOI: doi:10.1038/s41467-023-39262-2 ]
- Sia (25 kDa, Protein from synthetic construct)
- Serine incorporator 3 (52 kDa, Protein from Homo sapiens)
- Hserinc3-deltaicl4-sia (52 kDa, Complex from Homo sapiens)
Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7zyi
Q-score: 0.502
Liu H, Irobalieva RN, Bang-Sorensen R, Nosol K, Mukherjee S, Agrawal P, Stieger B, Kossiakoff AA, Locher KP
Cell Res (2022) 32 pp. 773-776 [ Pubmed: 35726088 DOI: doi:10.1038/s41422-022-00680-4 ]
- Glycochenodeoxycholic acid (449 Da, Ligand)
- Heavy chain of fab (25 kDa, Protein from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Light chain of fab (23 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- Sodium/bile acid cotransporter (ntcp) in complex with fab and nanobody (110 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nanobody (13 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)