Cryo-EM structure of the HIV-1 restriction factor human SERINC3
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7ru6
Q-score: 0.323
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ DOI: doi:10.1038/s41467-023-39262-2 Pubmed: 37474505 ]
- Sia (25 kDa, Protein from synthetic construct)
- Hserinc3-sia (55 kDa, Complex from Homo sapiens)
- Serine incorporator 3 (55 kDa, Protein from Homo sapiens)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7rug
Q-score: 0.244
Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M
Nat Commun (2023) 14 pp. 4368-4368 [ DOI: doi:10.1038/s41467-023-39262-2 Pubmed: 37474505 ]
- Hserinc3-deltaicl4-sia (52 kDa, Complex from Homo sapiens)
- Sia (25 kDa, Protein from synthetic construct)
- Serine incorporator 3 (52 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7niu
Q-score: 0.333
Nosol K, Bang-Sorensen R, Irobalieva RN, Erramilli SK, Stieger B, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34385322 DOI: doi:10.1073/pnas.2106702118 ]
- 4b1 fab-fragment heavy chain (25 kDa, Protein from Homo sapiens)
- Qa2 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- 4b1 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Isoform 2 of phosphatidylcholine translocator abcb4 (140 kDa, Protein from Homo sapiens)
- Nanodisc reconstituted human abcb4 in complex with 4b1-fab and qa2-fab (apo-inward-open conformation) (340 kDa, Complex)
- Qa2 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Qa2 fab-fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Phosphatidylcholine translocator abcb4 (Complex from Homo sapiens)
- 4b1 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab1
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Rhodopsin kinase, rhodopsin (Complex from Bos taurus)
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin stabilized by fab1 (Complex)
- Fab1 light chain (23 kDa, Protein from Homo sapiens)
- Fab1 heavy chain (24 kDa, Protein from Homo sapiens)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Fab heavy and light chains (Complex from Homo sapiens)
- Sangivamycin (309 Da, Ligand)
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6
Chen Q, Plasencia M, Li Z, Mukherjee S, Patra D, Chen CL, Klose T, Yao XQ, Kossiakoff AA, Chang L, Andrews PC, Tesmer JJG
Nature (2021) 595 pp. 600-605 [ Pubmed: 34262173 DOI: doi:10.1038/s41586-021-03721-x ]
- Rhodopsin kinase, rhodopsin (Complex from Bos taurus)
- Retinal (284 Da, Ligand)
- Rhodopsin kinase grk1 (61 kDa, Protein from Bos taurus)
- Rhodopsin kinase (grk1)-s5e/s488e/t489e in complex with rhodopsin stabilized by fab6 (Complex)
- Fab6 light chain (23 kDa, Protein from Homo sapiens)
- Rhodopsin (39 kDa, Protein from Bos taurus)
- Fab6 heavy chain (25 kDa, Protein from Homo sapiens)
- Fab6 heavy and light chains (Complex from Homo sapiens)
- Sangivamycin (309 Da, Ligand)
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6bf8
Q-score: 0.153
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
eLife (2018) 7 [ DOI: doi:10.7554/eLife.33572 Pubmed: 29596046 ]
- Insulin-degrading enzyme (111 kDa, Protein from Homo sapiens)
- Insulin degrading enzyme (100 kDa, Complex from Homo sapiens)