CryoEM structure of sNS1 complexed with Fab5E3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wur
Q-score: 0.427
Shu B, Ooi JSG, Tan AWK, Ng TS, Dejnirattisai W, Mongkolsapaya J, Fibriansah G, Shi J, Kostyuchenko VA, Screaton GR, Lok SM
Nat Commun (2022) 13 pp. 6756-6756 [ Pubmed: 36347841 DOI: doi:10.1038/s41467-022-34415-1 ]
- Fab 5e3 (Complex)
- Structure of dengue ns1 complexed with fab 5e3 (Complex from Dengue virus 2)
- Core protein (38 kDa, Protein from Dengue virus 2)
- Dengue ns1 (Complex from Homo sapiens)
- Fab 5e3 light chain (11 kDa, Protein from Homo sapiens)
- Fab 5e3 heavy chain (12 kDa, Protein from Homo sapiens)
CryoEM structure of a dimer of loose sNS1 tetramer
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7wus
Q-score: 0.402
Shu B, Ooi JSG, Tan AWK, Ng TS, Dejnirattisai W, Mongkolsapaya J, Fibriansah G, Shi J, Kostyuchenko VA, Screaton GR, Lok SM
Nat Commun (2022) 13 pp. 6756-6756 [ Pubmed: 36347841 DOI: doi:10.1038/s41467-022-34415-1 ]
- Dengue ns1 dimer of loose tetramer (Cellular component from Dengue virus 2)
- Core protein (38 kDa, Protein from Dengue virus 2)
CryoEM structure of stable sNS1 tetramer
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wut
Q-score: 0.368
Shu B, Ooi JSG, Tan AWK, Ng TS, Dejnirattisai W, Mongkolsapaya J, Fibriansah G, Shi J, Kostyuchenko VA, Screaton GR, Lok SM
Nat Commun (2022) 13 pp. 6756-6756 [ Pubmed: 36347841 DOI: doi:10.1038/s41467-022-34415-1 ]
CryoEM structure of loose sNS1 tetramer
Resolution: 8.3 Å
EM Method: Single-particle
Fitted PDBs: 7wuu
Q-score: 0.101
Shu B, Ooi JSG, Tan AWK, Ng TS, Dejnirattisai W, Mongkolsapaya J, Fibriansah G, Shi J, Kostyuchenko VA, Screaton GR, Lok SM
Nat Commun (2022) 13 pp. 6756-6756 [ Pubmed: 36347841 DOI: doi:10.1038/s41467-022-34415-1 ]
CryoEM structure of sNS1 hexamer
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 7wuv
Q-score: 0.055
Shu B, Ooi JSG, Tan AWK, Ng TS, Dejnirattisai W, Mongkolsapaya J, Fibriansah G, Shi J, Kostyuchenko VA, Screaton GR, Lok SM
Nat Commun (2022) 13 pp. 6756-6756 [ Pubmed: 36347841 DOI: doi:10.1038/s41467-022-34415-1 ]
- Core protein (34 kDa, Protein from Dengue virus 2)
- Ns1 hexamer (Cellular component from Dengue virus 2)
Resolution: 19.0 Å
EM Method: Single-particle
Fitted PDBs: 7dwt
Q-score: 0.022
Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe Jr JE, Lok SM
PLoS Pathog (2021) 17 pp. e1009331-e1009331 [ Pubmed: 33621239 DOI: doi:10.1371/journal.ppat.1009331 ]
- Dengue virus serotype 1 strain westpac 74 in complex with human antibody 1c19 fab (Complex from Dengue virus 1)
- Envelope protein (53 kDa, Protein from Dengue virus 1)
- Anti-dengue virus human monoclonal antibody 1c19 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Dengue virus 1 (Complex from Homo sapiens)
- Anti-dengue virus human monoclonal antibody 1c19 fab light chain (11 kDa, Protein from Homo sapiens)
- Antibody 1c19 fab (Complex)
Resolution: 19.0 Å
EM Method: Single-particle
Fitted PDBs: 7dwu
Q-score: 0.021
Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe Jr JE, Lok SM
PLoS Pathog (2021) 17 pp. e1009331-e1009331 [ DOI: doi:10.1371/journal.ppat.1009331 Pubmed: 33621239 ]
- Anti-dengue virus human monoclonal antibody 1c19 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Dengue virus 1 (Complex from Homo sapiens)
- Envelope protein (53 kDa, Protein from Dengue virus 1)
- Anti-dengue virus human monoclonal antibody 1c19 fab light chain (11 kDa, Protein from Homo sapiens)
- Dengue virus 1 (Complex from Dengue virus 1)
- Antibody 1c19 fab (Complex)
Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe Jr JE, Lok SM
PLoS Pathog (2021) 17 pp. e1009331-e1009331 [ DOI: doi:10.1371/journal.ppat.1009331 Pubmed: 33621239 ]
- Dengue virus serotype 2 strain pvp94/07 envelope protein (Protein from Dengue virus 2)
- Dengue virus 2 (Complex from Homo sapiens)
- Anti-dengue virus human monoclonal antibody 1c19 fab light chain (Protein from Homo sapiens)
- Dengue virus serotype 2 strain pvp94/07 membrane protein (Protein from Dengue virus 2)
- Anti-dengue virus human monoclonal antibody 1c19 fab heavy chain (Protein from Homo sapiens)
- Dengue virus serotype 2 strain pvp94/07 in complex with human antibody 1c19 fab (Complex from Dengue virus 2)
- Human antibody 1c19 fab (Complex)
Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe Jr JE, Lok SM
PLoS Pathog (2021) 17 pp. e1009331-e1009331 [ DOI: doi:10.1371/journal.ppat.1009331 Pubmed: 33621239 ]
- Dengue virus 2 (Complex)
- Dengue virus serotype 2 strain pvp94/07 envelope protein (Protein from Dengue virus 2)
- Anti-dengue virus human monoclonal antibody 1c19 fab heavy chain (Protein from Homo sapiens)
- Human antibody 1c19 fab (Complex)
- Anti-dengue virus human monoclonal antibody 1c19 fab light chain (Protein from Homo sapiens)
- Dengue virus serotype 2 strain pvp94/07 in complex with human antibody 1c19 fab (Complex from Dengue virus 2)
- Dengue virus serotype 2 strain pvp94/07 membrane protein (Protein from Dengue virus 2)
Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124
Resolution: 5.2 Å
EM Method: Single-particle
Fitted PDBs: 7cvy
Q-score: 0.178
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- Fab heavy chain (23 kDa, Protein from Mus musculus)
- Chikungunya virus in complex with fab fragments of mab chk-124 (Complex)
- Fab light chain (23 kDa, Protein from Mus musculus)
- Fab region of chk-124 (Cellular component from Mus musculus)
- Chikungunya virus (Cellular component from Chikungunya virus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)