Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-263
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7cvz
Q-score: 0.281
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- Chikungunya virus in complex with fab fragments of mab chk-263 (Complex)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Fab light chain (23 kDa, Protein from Mus musculus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Chikungunya virus (Cellular component from Chikungunya virus)
- Chk-263 fab (Cellular component from Mus musculus)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7cw2
Q-score: 0.316
Zhou QF, Fox JM, Earnest JT, Ng TS, Kim AS, Fibriansah G, Kostyuchenko VA, Shi J, Shu B, Diamond MS, Lok SM
PNAS (2020) 117 pp. 27637-27645 [ DOI: doi:10.1073/pnas.2008051117 Pubmed: 33087569 ]
- E2 glycoprotein (46 kDa, Protein from Chikungunya virus)
- Fab heavy chain (22 kDa, Protein from Mus musculus)
- Localized reconstruction of subregions around the icosahedral 5-fold vertex of chikv:chk-263 fab complex (Complex)
- Fab light chain (23 kDa, Protein from Mus musculus)
- E1 glycoprotein (47 kDa, Protein from Chikungunya virus)
- Capsid protein (16 kDa, Protein from Chikungunya virus)
- Chikungunya virus (Cellular component from Chikungunya virus)
- Fab region of chk-263 (Cellular component from Mus musculus)
Cryo-EM structure of zika virus complexed with Fab SIgN-3C at pH 8.0
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7bua
Q-score: 0.249
Zhang S, Loy T, Ng TS, Lim XN, Chew SV, Tan TY, Xu M, Kostyuchenko VA, Tukijan F, Shi J, Fink K, Lok SM
Cell Rep (2020) 31 pp. 107584-107584 [ DOI: doi:10.1016/j.celrep.2020.107584 Pubmed: 32348755 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of zika virus with sign-3c fab (Complex from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Sign-3c fab (Complex)
- Zika virus (Complex from Homo sapiens)
- Zika virus m protein (8 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Genome polyprotein (54 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Sign-3c fab heavy chain (14 kDa, Protein from Homo sapiens)
- Sign-3c fab light chain (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 6.5
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7bub
Q-score: 0.376
Zhang S, Loy T, Ng TS, Lim XN, Chew SV, Tan TY, Xu M, Kostyuchenko VA, Tukijan F, Shi J, Fink K, Lok SM
Cell Rep (2020) 31 pp. 107584-107584 [ DOI: doi:10.1016/j.celrep.2020.107584 Pubmed: 32348755 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dengue virus serotype 2 (Complex)
- Dengue virus serotype 2 m protein (8 kDa, Protein from Dengue virus 2)
- Dengue virus serotype2 e protein (54 kDa, Protein from Dengue virus 2)
- Sign-3c fab (Complex from Dengue virus 2)
- Sign-3c fab heavy chain (14 kDa, Protein from Homo sapiens)
- Sign-3c fab light chain (11 kDa, Protein from Homo sapiens)
- Complex of dengue virus serotype 2 with sign-3c fab (Complex from Homo sapiens)
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 8.0
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7bud
Q-score: 0.334
Zhang S, Loy T, Ng TS, Lim XN, Chew SV, Tan TY, Xu M, Kostyuchenko VA, Tukijan F, Shi J, Fink K, Lok SM
Cell Rep (2020) 31 pp. 107584-107584 [ DOI: doi:10.1016/j.celrep.2020.107584 Pubmed: 32348755 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dengue virus serotype 2 (Complex)
- Dengue virus serotype 2 m protein (8 kDa, Protein from Dengue virus 2)
- Sign-3c fab (Complex from Dengue virus 2)
- Sign-3c fab heavy chain (14 kDa, Protein from Homo sapiens)
- Dengue virus serotype 2 e protein (54 kDa, Protein from Dengue virus 2)
- Sign-3c fab light chain (11 kDa, Protein from Homo sapiens)
- Complex of dengue virus serotype 2 with sign-3c fab (Complex from Homo sapiens)
Cryo-EM structure of zika virus complexed with Fab C10 at pH 6.5
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5h30
Q-score: 0.284
Zhang S, Kostyuchenko VA, Ng T-S, Lim X-N, Ooi JSG, Lambert S, Tan TY, Widman DG, Shi J, Baric RS, Lok S-M
Nat Commun (2016) 7 pp. 13679-13679 [ Pubmed: 27882950 DOI: doi:10.1038/ncomms13679 ]
- Strutural protein m (8 kDa, Protein from Zika virus)
- Zika virus complexed with c10 fab at ph 6.5 (Complex)
- Igg c10 heavy chain (14 kDa, Protein from Homo sapiens)
- Fab c10 (Complex)
- Igg c10 light chain (11 kDa, Protein from Homo sapiens)
- Structural protein e (54 kDa, Protein from Zika virus)
- Zika virus (Complex from Zika virus)
Cryo-EM structure of zika virus complexed with Fab C10 at pH 8.0
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5h37
Q-score: 0.39
Zhang S, Kostyuchenko VA, Ng T-S, Lim X-N, Ooi JSG, Lambert S, Tan TY, Widman DG, Shi J, Baric RS, Lok S-M
Nat Commun (2016) 7 pp. 13679-13679 [ DOI: doi:10.1038/ncomms13679 Pubmed: 27882950 ]
- Zika virus complexed with c10 fab at ph 8.0 (Complex)
- C10 igg light chain variable region (11 kDa, Protein from Homo sapiens)
- C10 igg heavy chain variable region (14 kDa, Protein from Homo sapiens)
- Structural protein e (54 kDa, Protein from Zika virus)
- Strutural protein m (8 kDa, Protein from Zika virus)
- Zika virus (Complex from Zika virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C10 fab (Complex)
Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 4cbf
Q-score: 0.232
Kostyuchenko VA, Chew PL, Ng TS, Lok SM
J Virol (2014) 88 pp. 477-482 [ Pubmed: 24155405 DOI: doi:10.1128/JVI.02641-13 ]
4.5A Electron cryomicroscopy reconstruction of mature Dengue virus serotype 1
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 4cct
Q-score: 0.106
Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM
J Virol (2013) 87 pp. 7700-7707 [ DOI: doi:10.1128/JVI.00197-13 Pubmed: 23637416 ]
- Dengue virus 1 (14 MDa, Virus from Dengue virus 1)
- Mature dengue virus serotype 1 (14 MDa, Sample)