Structure of human full-length ancestral TRPV6 channel in apo open state
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9cuh
Q-score: 0.56
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Ancestral htrpv6 tetramer in open apo state (370 kDa, Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human full-length ancestral TRPV6 channel in Calmodulin-bound state
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 9cui
Q-score: 0.468
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ancestral htrpv6 tetramer in complex with calmodulin (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
Structure of human full-length derived TRPV6 channel in apo open state
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 9cuj
Q-score: 0.569
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Derived htrpv6 tetramer in open apo state (370 kDa, Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of human full-length derived TRPV6 channel in Calmodulin-bound state
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 9cuk
Q-score: 0.482
Neuberger A, Shalygin A, Trofimov YA, Veretenenko II, Nadezhdin KD, Krylov NA, Gudermann T, Efremov RG, Chubanov V, Sobolevsky AI
Structure (2025) 33 pp. 91-103.e5 [ DOI: doi:10.1016/j.str.2024.10.018 Pubmed: 39500315 ]
- Water (18 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (87 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Derived htrpv6 tetramer in complex with calmodulin (370 kDa, Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8sp8
Q-score: 0.515
Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 4630-4630 [ DOI: doi:10.1038/s41467-023-40362-2 Pubmed: 37532722 ]
- Chloride ion (35 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sample 1 (76 kDa, Complex from Homo sapiens)
- Tetrahydrocannabivarin (286 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (76 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8foa
Q-score: 0.546
Neuberger A, Trofimov YA, Yelshanskaya MV, Nadezhdin KD, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 2659-2659 [ DOI: doi:10.1038/s41467-023-38352-5 Pubmed: 37160865 ]
- Transient receptor potential cation channel subfamily v member 6 (83 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Sample 1 (83 kDa, Complex from Homo sapiens)
- Genistein (270 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of human TRPV6 in the open state
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8fob
Q-score: 0.468
Neuberger A, Trofimov YA, Yelshanskaya MV, Nadezhdin KD, Krylov NA, Efremov RG, Sobolevsky AI
Nat Commun (2023) 14 pp. 2659-2659 [ DOI: doi:10.1038/s41467-023-38352-5 Pubmed: 37160865 ]
- Water (18 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 6 (83 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Sample 1 (83 kDa, Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius
Resolution: 1.98 Å
EM Method: Single-particle
Fitted PDBs: 7mij
Q-score: 0.661
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ Pubmed: 34239124 DOI: doi:10.1038/s41594-021-00615-4 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7mik
Q-score: 0.54
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ Pubmed: 34239124 DOI: doi:10.1038/s41594-021-00615-4 ]
- Sodium ion (22 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)
Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7mil
Q-score: 0.408
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol (2021) 28 pp. 564-572 [ Pubmed: 34239124 DOI: doi:10.1038/s41594-021-00615-4 ]
- Sodium ion (22 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 3 (924 kDa, Complex from Mus musculus)
- Transient receptor potential cation channel subfamily v member 3 (92 kDa, Protein from Mus musculus)