Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7tyz
Q-score: 0.391
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Darpin fsr22 (23 kDa, Protein from Escherichia phage EcSzw-2Escherichia coli)
- Darpin fsr22 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7tz0
Q-score: 0.228
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 8dw2
Q-score: 0.351
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ Pubmed: 36411391 DOI: doi:10.1038/s41589-022-01193-2 ]
- Darpin sr22 in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Sr22 (16 kDa, Protein from Escherichia phage EcSzw-2)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 8dw3
Q-score: 0.337
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Darpin sr16m in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
- Anti-sars-cov-2 darpin sr16m (16 kDa, Protein from Homo sapiens)
Resolution: 7.3 Å
EM Method: Single-particle
Fitted PDBs: 7xxl
Q-score: 0.033
Ku Z, Xie X, Lin J, Gao P, Wu B, El Sahili A, Su H, Liu Y, Ye X, Tan EY, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Zou J, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z
Nat Commun (2022) 13 pp. 5552-5552 [ DOI: doi:10.1038/s41467-022-33284-y Pubmed: 36138032 ]
- Rbd bound to fab14 (Complex)
- Receptor binding domain of wild-type spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab14 heavy chain (25 kDa, Protein from Homo sapiens)
- Fab14 (Complex from Homo sapiens)
- Fab14 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 7kbb
Q-score: 0.274
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- Hcmv pentamer (refinement focused on three of the subunits) (Complex from Human betaherpesvirus 5)
- Hcmv pentamer bound by antibodies 2-18 and 8i21 (280 kDa, Complex)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Fab 8i21 (Complex from Homo sapiens)
- 8i21 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- 8i21 fab light chain (23 kDa, Protein from Homo sapiens)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-18 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Fab 2-18 (Complex from Homo sapiens)
- 2-18 fab light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7m22
Q-score: 0.409
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Neuropilin-2 (65 kDa, Protein from Homo sapiens)
- The ectodomain of the hcmv pentamer (Complex from Human betaherpesvirus 5)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- The ectodomain of the hcmv pentamer bound by domains a1a2b1b2 of human neuropilin 2 (230 kDa, Complex)
- Calcium ion (40 Da, Ligand)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Domains a1a2b1b2 of human neuropilin 2 (Complex from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7m30
Q-score: 0.323
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- 2-25 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 1-32 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 1-103 fab (Complex from Homo sapiens)
- 1-103 fab light chain (22 kDa, Protein from Homo sapiens)
- Hcmv pentamer (Complex from Human betaherpesvirus 5)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- 1-32 fab light chain (23 kDa, Protein from Homo sapiens)
- 1-103 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- 1-32 fab (Complex from Homo sapiens)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-25 fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Quaternary complex of the hcmv pentamer bound by fabs 1-103, 1-32, and 2-25 (310 kDa, Complex)
- Envelope glycoprotein l (27 kDa, Protein from Human cytomegalovirus)
- 2-25 fab (Complex from Homo sapiens)
Beta-propiolactone treated coxsackievirus A16 mature virion
Fan C, Ye X, Ku Z, Kong L, Liu Q, Xu C, Cong Y, Huang Z
J Virol (2017) 91 [ Pubmed: 28148783 DOI: doi:10.1128/JVI.00038-17 ]
- Coxsackievirus a16 (5 MDa, Virus from coxsackievirus A16)