Cryo electron micrographs of Coxsackievirus A9 bound with CL213
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 20 (CL300)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 15 (CL278)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 16 (CL298)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 17 (CL301)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 14 (CL275)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Cryo electron micrographs of Coxsackievirus A9 bound with compound 19 (CL313)
Tammaro C, Plavec Z, Myllymäki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Sciò P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomäki V, Butcher SJ, Poce G
Journal of medicinal chemistry (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: 10.1021/acs.jmedchem.4c00701 ]
Image sets:
Coxsackievirus A9 bound with compound 20 (CL300)
Resolution: 2.26 Å
EM Method: Single-particle
Fitted PDBs: 8s7j
Q-score: 0.598
Tammaro C, Plavec Z, Myllymaki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Scio P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomaki V, Butcher SJ, Poce G
J Med Chem (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: doi:10.1021/acs.jmedchem.4c00701 ]
- Myristic acid (228 Da, Ligand)
- Capsid protein vp2 (28 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Capsid protein vp1 (33 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Capsid protein vp3 (26 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Human coxsackievirus a9 (strain griggs) (8 MDa, Virus from Human coxsackievirus A9 (strain Griggs))
- Capsid protein vp4 (7 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- ~{n}-[(4-methoxyphenyl)methyl]-4-[(4-methylpiperazin-1-yl)methyl]aniline (325 Da, Ligand)
Coxsackievirus A9 bound with compound 14 (CL275)
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 9exi
Q-score: 0.584
Tammaro C, Plavec Z, Myllymaki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Scio P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomaki V, Butcher SJ, Poce G
J Med Chem (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: doi:10.1021/acs.jmedchem.4c00701 ]
- Myristic acid (228 Da, Ligand)
- Capsid protein vp1 (32 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Coxsackievirus a9 (8 MDa, Virus from Coxsackievirus A9)
- Capsid protein vp2 (27 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- 4-[(4-methylpiperazin-1-yl)methyl]-n-[[4-(trifluoromethyl)phenyl]methyl]aniline (363 Da, Ligand)
- Capsid protein vp3 (26 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Capsid protein vp4 (7 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
Coxsackievirus A9 bound with compound 16 (CL298)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 9fa9
Q-score: 0.553
Tammaro C, Plavec Z, Myllymaki L, Mitchell C, Consalvi S, Biava M, Ciogli A, Domanska A, Leppilampi V, Buckner C, Manetto S, Scio P, Coluccia A, Laajala M, Dondio GM, Bigogno C, Marjomaki V, Butcher SJ, Poce G
J Med Chem (2024) 67 pp. 17144-17161 [ Pubmed: 39292620 DOI: doi:10.1021/acs.jmedchem.4c00701 ]
- Capsid protein vp1 (32 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Capsid protein vp2 (28 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- Coxsackievirus a9 (8 MDa, Virus from Coxsackievirus A9)
- Capsid protein vp3 (26 kDa, Protein from Human coxsackievirus A9 (strain Griggs))
- ~{n}-[(2-fluorophenyl)methyl]-4-[(4-methylpiperazin-1-yl)methyl]aniline (313 Da, Ligand)
- Capsid protein vp4 (7 kDa, Protein from Human coxsackievirus A9 (strain Griggs))