Cryo-EM structure of prefusion-stabilized influenza B hemagglutinin
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8uad
Q-score: 0.598
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza B virus)
- Hemagglutinin ha2 chain (19 kDa, Protein from Influenza B virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion-stabilized influenza b hemagglutinin (Complex from Influenza B virus)
Prefusion-stabilized trimer of FluB-HA under low pH conditions
Juraszek J, Milder FJ, Yu X, Blokland S, van Overveld D, Abeywickrema P, Tamara S, Sharma S, Rutten L, Bakkers MJG, Langedijk JPM
Pnas Nexus (2024) 3 pp. pgae462-pgae462 [ DOI: doi:10.1093/pnasnexus/pgae462 Pubmed: 39445049 ]
Cryo-EM structure of Prefusion RSV F (RSV220975)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 9b2x
Q-score: 0.525
Bakkers MJG, Cox F, Koornneef A, Yu X, van Overveld D, Le L, van den Hoogen W, Vaneman J, Thoma A, Voorzaat R, Tettero L, Juraszek J, van der Fits L, Zahn R, Langedijk JPM
Nat Microbiol (2024) 9 pp. 3254-3267 [ Pubmed: 39567664 DOI: doi:10.1038/s41564-024-01860-1 ]
- Prefusion rsv f (rsv220975) (Complex from Human metapneumovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (58 kDa, Protein from Human orthopneumovirus)
Cryo-EM structure of HMPV (MPV-2cREKR)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8vt2
Q-score: 0.569
Bakkers MJG, Ritschel T, Tiemessen M, Dijkman J, Zuffiano AA, Yu X, van Overveld D, Le L, Voorzaat R, van Haaren MM, de Man M, Tamara S, van der Fits L, Zahn R, Juraszek J, Langedijk JPM
Nat Commun (2024) 15 pp. 6270-6270 [ DOI: doi:10.1038/s41467-024-50659-5 Pubmed: 39054318 ]
Cryo-EM structure of HMPV (MPV-2cREKR)
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8vt3
Q-score: 0.567
Bakkers MJG, Ritschel T, Tiemessen M, Dijkman J, Zuffiano AA, Yu X, van Overveld D, Le L, Voorzaat R, van Haaren MM, de Man M, Tamara S, van der Fits L, Zahn R, Juraszek J, Langedijk JPM
Nat Commun (2024) 15 pp. 6270-6270 [ DOI: doi:10.1038/s41467-024-50659-5 Pubmed: 39054318 ]
- Prefusion of hmpv (mpv-2crekr), n-fragment (8 kDa, Protein from Human metapneumovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Prefusion of hmpv (mpv-2crekr) trimer complex (Complex from Human metapneumovirus)
- Prefusion of hmpv (mpv-2crekr), c-fragment (41 kDa, Protein from Human metapneumovirus)
Prefusion-stabilized Respirovirus type 3 Fusion protein
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8v5a
Q-score: 0.469
Langedijk JPM, Cox F, Johnson NV, van Overveld D, Le L, van den Hoogen W, Voorzaat R, Zahn R, van der Fits L, Juraszek J, McLellan JS, Bakkers MJG
Nat Commun (2024) 15 pp. 4629-4629 [ DOI: doi:10.1038/s41467-024-48059-w Pubmed: 38821950 ]
- Trimeric human respirovirus 3 fusion protein bound to 3 copies of nanobody 4c06 (232 kDa, Complex from Human respirovirus 3)
- Fusion glycoprotein f0 (54 kDa, Protein from Human respirovirus 3)
- Camelid nanobody 4c06 (12 kDa, Protein from Lama glama)
Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 4C03 and 4C06
Johnson NV, van Scherpenzeel RC, Bakkers MJG, Ramamohan AR, van Overveld D, Le L, Langedijk JPM, Kolkman JA, McLellan JS
Nat Commun (2024) 15 pp. 5458-5458 [ DOI: doi:10.1038/s41467-024-49757-1 Pubmed: 38937429 ]
- Camelid nanobody 4c03 (13 kDa, Protein from Lama glama)
- Prefusion human respirovirus 3 fusion protein bound to camelid nanobodies 4c03 and 4c06 (277 kDa, Complex from Human respirovirus 3)
- Fusion glycoprotein f0 (55 kDa, Protein from Human respirovirus 3)
- Camelid nanobody 4c06 (12 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the Human Respirovirus 3 Fusion Protein Bound to Camelid Nanobodies 1D10 and 4C06
Johnson NV, van Scherpenzeel RC, Bakkers MJG, Ramamohan AR, van Overveld D, Le L, Langedijk JPM, Kolkman JA, McLellan JS
Nat Commun (2024) 15 pp. 5458-5458 [ DOI: doi:10.1038/s41467-024-49757-1 Pubmed: 38937429 ]
- Camelid nanobody 4c06 (12 kDa, Protein from Lama glama)
- Prefusion human respirovirus 3 fusion protein bound to camelid nanobodies 1d10 and 4c06 (277 kDa, Complex from Human respirovirus 3)
- Camelid nanobody 1d10 (12 kDa, Protein from Lama glama)
- Fusion glycoprotein f0 (57 kDa, Protein from Human respirovirus 3)
Structure of Covid Spike variant deltaN135 in fully closed form
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8fu7
Q-score: 0.437
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM
PLoS Pathog (2023) 19 pp. e1011308-e1011308 [ DOI: doi:10.1371/journal.ppat.1011308 Pubmed: 37126534 ]
Structure of Covid Spike variant deltaN135 with one erect RBD
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8fu8
Q-score: 0.457
Yu X, Juraszek J, Rutten L, Bakkers MJG, Blokland S, Melchers JM, van den Broek NJF, Verwilligen AYW, Abeywickrema P, Vingerhoets J, Neefs JM, Bakhash SAM, Roychoudhury P, Greninger A, Sharma S, Langedijk JPM
PLoS Pathog (2023) 19 pp. e1011308-e1011308 [ DOI: doi:10.1371/journal.ppat.1011308 Pubmed: 37126534 ]