Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 1)
Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale Jr M, Blancas-Mejia LM, Yen HL, Silva DA
Science (2020) 370 pp. 1208-1214 [ Pubmed: 33154107 DOI: doi:10.1126/science.abe0075 ]
- Ctc-445.2 inhibitor (Protein from Homo sapiens)
- Ternary complex of ctc445.2 inhibitor with sars-cov-2 s 6p glycoprotin (600 kDa, Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ctc-445.2 inhibitor (Complex from Homo sapiens)
- Sars-cov-2 6p stabilized spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 2)
Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale Jr M, Blancas-Mejia LM, Yen HL, Silva DA
Science (2020) 370 pp. 1208-1214 [ Pubmed: 33154107 DOI: doi:10.1126/science.abe0075 ]
- Ctc-445.2 inhibitor (Protein from Homo sapiens)
- Ternary complex of ctc445.2 inhibitor with sars-cov-2 s 6p glycoprotin (600 kDa, Complex)
- Sars-cov-2 stabilized 6p spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ctc-445.2 inhibitor (Complex from Homo sapiens)
Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 4)
Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale Jr M, Blancas-Mejia LM, Yen HL, Silva DA
Science (2020) 370 pp. 1208-1214 [ Pubmed: 33154107 DOI: doi:10.1126/science.abe0075 ]
- Ctc-445.2 inhibitor (Protein from Homo sapiens)
- Ternary complex of ctc445.2 inhibitor with sars-cov-2 s 6p glycoprotin (600 kDa, Complex)
- Sars-cov-2 stabilized 6p spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ctc-445.2 inhibitor (Complex from Homo sapiens)
Structure of the SARS-CoV-2 S 6P trimer in complex with the ACE2 protein decoy, CTC-445.2 (State 4)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7kl9
Q-score: 0.352
Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale Jr M, Blancas-Mejia LM, Yen HL, Silva DA
Science (2020) 370 pp. 1208-1214 [ Pubmed: 33154107 DOI: doi:10.1126/science.abe0075 ]
- Ctc-445.2 inhibitor (17 kDa, Protein from Homo sapiens)
- Ternary complex of ctc445.2 inhibitor with sars-cov-2 s 6p glycoprotin (600 kDa, Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ctc-445.2 inhibitor (Complex from Homo sapiens)