Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6hug
Q-score: 0.55
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with picrotoxin and megabody mb38. (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with picrotoxin and megabody mb38. (Complex from Lama glama)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with picrotoxin and megabody mb38. (330 kDa, Complex)
- Gamma-aminobutyric acid receptor subunit alpha-1 (49 kDa, Protein from Bos taurus)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- Megabody mb38 (57 kDa, Protein from Lama glama)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6huj
Q-score: 0.541
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Megabody mb38 (Complex from Lama glama)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- (1ar,2ar,3s,6r,6as,8as,8br,9r)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3h)-dione (292 Da, Ligand)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with picrotoxin, gaba and megabody mb38. (330 kDa, Complex)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3, gamma-aminobutyric acid receptor subunit gamma-2 (Complex from Homo sapiens)
- Megabody mb38 (57 kDa, Protein from Lama glama)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 6huk
Q-score: 0.455
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- Bicuculline methochloride (367 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with bicuculline and megabody mb38. (330 kDa, Complex)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Megabody mb38 (Complex from Lama glama)
- Megabody mb38 (57 kDa, Protein from Lama glama)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r (Complex from Homo sapiens)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 6huo
Q-score: 0.514
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- 8-chloro-1-methyl-6-phenyl-4h-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (308 Da, Ligand)
- Heteromeric alpha1beta3gamma2l gaba(a)r (Complex from Homo sapiens)
- Megabody mb38 (Complex from Lama glama)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Cryoem structure of human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with alprazolam (xanax), gaba and megabody mb38. (330 kDa, Complex)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Megabody mb38 (57 kDa, Protein from Lama glama)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 6hup
Q-score: 0.467
Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 454-459 [ DOI: doi:10.1038/s41586-018-0832-5 Pubmed: 30602790 ]
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1,gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Heteromeric alpha1beta3gamma2l gaba(a)r (Complex from Homo sapiens)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Human full-length heteromeric alpha1beta3gamma2l gaba(a)r in complex with diazepam (valium), gaba and megabody mb38. (330 kDa, Complex)
- Megabody mb38 (Complex from Lama glama)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Megabody mb38 (57 kDa, Protein from Lama glama)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6i53
Q-score: 0.529
Laverty D, Desai R, Uchanski T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR
Nature (2019) 565 pp. 516-520 [ DOI: doi:10.1038/s41586-018-0833-4 Pubmed: 30602789 ]
- Human alpha1-beta3-gamma2 gaba-a receptor in complex with megabody38 and in lipid nanodiscs (400 kDa, Complex)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Megabody38 (Complex from Lama glama)
- Human alpha1-beta3-gamma2 gaba-a receptor (Complex from Homo sapiens)
- Megabody38 (13 kDa, Protein from Lama glama)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)