Eukaryotic translation initiation factor 2B tetramer
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tqo
Q-score: 0.495
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
Nat Chem Biol (2024) 20 pp. 422-431 [ Pubmed: 37945896 DOI: doi:10.1038/s41589-023-01453-9 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor 2b decamer (530 kDa, Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tqz
Q-score: 0.519
Lawrence RE, Shoemaker SR, Deal A, Sangwan S, Anand AA, Wang L, Marqusee S, Walter P
Nat Chem Biol (2024) 20 pp. 422-431 [ Pubmed: 37945896 DOI: doi:10.1038/s41589-023-01453-9 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (35 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor 2b decamer (530 kDa, Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7rlo
Q-score: 0.546
Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P
Nat Commun (2021) 12 pp. 7103-7103 [ DOI: doi:10.1038/s41467-021-26164-4 Pubmed: 34876554 ]
- Translation initiation factor eif-2b subunit (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Non-structural protein ns-s (30 kDa, Protein from Sandfly fever sicilian virus)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Nss protein of sandfly fever sicilian phlebovirus (Complex from Sandfly fever Sicilian virus)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2b in complex with sfsv nss (500 kDa, Complex)
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the pre-GAP state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6wj2
Q-score: 0.479
Fromm SA, Lawrence RE, Hurley JH
Nat Struct Mol Biol (2020) 27 pp. 1017-1023 [ DOI: doi:10.1038/s41594-020-0490-9 Pubmed: 32868926 ]
- Dimeric rag gtpases (Complex from Homo sapiens)
- Ragulator complex protein lamtor3 (13 kDa, Protein from Homo sapiens)
- 9-{5-o-[(s)-hydroxy{[(r)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-l-arabinofuranosyl}-3,9-dihydro-1h-purine-2,6-dione (540 Da, Ligand)
- Ragulator complex protein lamtor4 (10 kDa, Protein from Homo sapiens)
- Ras-related gtp-binding protein c (44 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor2 (13 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor1 (18 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Pentameric ragulator (Complex from Homo sapiens)
- Complex of pentameric ragulator, dimeric rag gtpases and slc38a9 (170 kDa, Complex)
- Slc38a9 (Complex from Homo sapiens)
- Ras-related gtp-binding protein a (39 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Sodium-coupled neutral amino acid transporter 9 (13 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor5 (18 kDa, Protein from Homo sapiens)
CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6wj3
Q-score: 0.358
Fromm SA, Lawrence RE, Hurley JH
Nat Struct Mol Biol (2020) 27 pp. 1017-1023 [ DOI: doi:10.1038/s41594-020-0490-9 Pubmed: 32868926 ]
- Dimeric rag gtpases (Complex from Homo sapiens)
- Ragulator complex protein lamtor3 (13 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor4 (10 kDa, Protein from Homo sapiens)
- Ras-related gtp-binding protein c (44 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor2 (13 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor1 (18 kDa, Protein from Homo sapiens)
- Pentameric ragulator (Complex from Homo sapiens)
- Complex of pentameric ragulator, dimeric rag gtpases and slc38a9 (170 kDa, Complex)
- Slc38a9 (Complex from Homo sapiens)
- Ras-related gtp-binding protein a (39 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Xanthosine diphosphate (444 Da, Ligand)
- Sodium-coupled neutral amino acid transporter 9 (13 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor5 (18 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6nzd
Q-score: 0.326
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
Science (2019) 366 pp. 971-977 [ DOI: doi:10.1126/science.aax0364 Pubmed: 31672913 ]
- Ragulator complex protein lamtor3 (13 kDa, Protein from Homo sapiens)
- 9-{5-o-[(s)-hydroxy{[(r)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-l-arabinofuranosyl}-3,9-dihydro-1h-purine-2,6-dione (540 Da, Ligand)
- Ragulator complex protein lamtor4 (10 kDa, Protein from Homo sapiens)
- Ras-related gtp-binding protein c (44 kDa, Protein from Homo sapiens)
- Flcn-fnip2-raga-ragc-ragulator complex (340 kDa, Complex from Homo sapiens)
- Ragulator complex protein lamtor1 (18 kDa, Protein from Homo sapiens)
- Ragulator complex protein lamtor2 (13 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related gtp-binding protein a (36 kDa, Protein from Homo sapiens)
- Folliculin-interacting protein 2 (122 kDa, Protein from Homo sapiens)
- Folliculin (69 kDa, Protein from Homo sapiens)
- Hepatitis b virus x interacting protein (18 kDa, Protein from Homo sapiens)
Cryo-EM Map of the active Ragulator-RagA-RagC Complex
Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
Science (2019) 366 pp. 971-977 [ DOI: doi:10.1126/science.aax0364 Pubmed: 31672913 ]
- Active raga-ragc-ragulator complex (150 kDa, Complex from Homo sapiens)