Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bir
Q-score: 0.549
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Nanobody (Complex from Lama glama)
- Complex of the mammalian peptide transporter pept2 with nanobody and bound cefadroxil (Complex from Rattus norvegicus)
- Pept2 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
- Cefadroxil (363 Da, Ligand)
Cryo-EM structure of the mammalian peptide transporter PepT2 bound to amoxicillin
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9bis
Q-score: 0.523
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Nanobody (Complex from Lama glama)
- Complex of the mammalian peptide transporter pept2 with nanobody and bound amoxicillin (Complex from Rattus norvegicus)
- Pept2 (Complex from Rattus norvegicus)
- 2-{1-[2-amino-2-(4-hydroxy-phenyl)-acetylamino]-2-oxo-ethyl}-5,5-dimethyl-thiazolidine-4-carboxylic acid (367 Da, Ligand)
- Nanobody (14 kDa, Protein from Lama glama)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bit
Q-score: 0.539
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Complex of the mammalian peptide transporter pept2 with nanobody and bound cloxacillin, pose 1 (Complex from Rattus norvegicus)
- Nanobody (Complex from Lama glama)
- Cloxacillin (435 Da, Ligand)
- Pept2 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9biu
Q-score: 0.548
Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2024) 15 pp. 8755-8755 [ DOI: doi:10.1038/s41467-024-53096-6 Pubmed: 39384780 ]
- Nanobody (Complex from Lama glama)
- Cloxacillin (435 Da, Ligand)
- Pept2 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)
- Complex of the mammalian peptide transporter pept2 with nanobody and bound cloxacillin, pose 2 (Complex from Rattus norvegicus)
Cryo EM structure of System XC- in complex with glutamate
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7p9u
Q-score: 0.399
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2021) 12 pp. 7147-7147 [ DOI: doi:10.1038/s41467-021-27414-1 Pubmed: 34880232 ]
- Glutamic acid (147 Da, Ligand)
- System xc- (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (69 kDa, Protein from Homo sapiens)
- Cystine/glutamate transporter (56 kDa, Protein from Homo sapiens)
Cryo EM structure of System XC-
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7p9v
Q-score: 0.45
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S
Nat Commun (2021) 12 pp. 7147-7147 [ DOI: doi:10.1038/s41467-021-27414-1 Pubmed: 34880232 ]
- System xc- (Complex from Homo sapiens)
- 4f2 cell-surface antigen heavy chain (69 kDa, Protein from Homo sapiens)
- Cystine/glutamate transporter (56 kDa, Protein from Homo sapiens)
Cryo-EM structure of the mammalian peptide transporter PepT2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7nqk
Q-score: 0.462
Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S
Sci Adv (2021) 7 [ Pubmed: 34433568 DOI: doi:10.1126/sciadv.abh3355 ]
- Complex of the mammalian peptide transporter pept2 with nanobody (Complex)
- Nanobody (Complex from Lama glama)
- Pept2 (Complex from Rattus norvegicus)
- Nanobody (14 kDa, Protein from Lama glama)
- Solute carrier family 15 member 2 (82 kDa, Protein from Rattus norvegicus)