Human urate transporter 1 URAT1 in apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9b1f
Q-score: 0.508
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Human urate transporter 1 in apo state (Complex from Homo sapiens)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human urate transporter 1 URAT1 in complex with dotinurad
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9b1g
Q-score: 0.546
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Human urate transporter 1 in complex with dotinurad (Complex from Homo sapiens)
- Dotinurad (358 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human urate transporter 1 URAT1 in complex with lesinurad
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9b1h
Q-score: 0.524
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Human urate transporter in complex with lesinurad (Complex from Homo sapiens)
- Lesinurad (404 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human urate transporter 1 URAT1 in complex with verinurad
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9b1i
Q-score: 0.405
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Verinurad (348 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human urate transporter 1 in complex with verinurad (Complex from Homo sapiens)
Urate bound human URAT1 in the inward-facing state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9b1j
Q-score: 0.494
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- Uric acid (168 Da, Ligand)
- Urate bound human urat1 in the inward-facing state (Complex from Homo sapiens)
Urate bound human URAT1 in the occluded state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9b1k
Q-score: 0.448
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Uric acid (168 Da, Ligand)
- Urate bound human urat1 in the occluded state. (Complex from Homo sapiens)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
Urate bound human URAT1 in the outward-facing state.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9b1l
Q-score: 0.512
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Uric acid (168 Da, Ligand)
- Urate bound human urat1 in the outward-facing state. (Complex from Homo sapiens)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
Pyrazinoate bound human URAT1 in the inward-facing state (site1)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9b1m
Q-score: 0.524
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Pyrazinoate bound human urat1 in the inward-facing state (site1). (Complex from Homo sapiens)
- Pyrazine-2-carboxylic acid (124 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Pyrazinoate bound human URAT1 in the inward-facing state (site2)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9b1n
Q-score: 0.509
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pyrazine-2-carboxylic acid (124 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- Pyrazinoate bound human urat1 in the inward-facing state (site2). (Complex from Homo sapiens)
Pyrazinoate bound human URAT1 in the inward-facing state (site3)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9b1o
Q-score: 0.516
Cell Res (2024) 34 pp. 776-787 [ Pubmed: 39245778 DOI: doi:10.1038/s41422-024-01023-1 ]
- Pyrazinoate bound human urat1 in the inward-facing state (site3). (Complex from Homo sapiens)
- Pyrazine-2-carboxylic acid (124 Da, Ligand)
- Solute carrier family 22 member 12 (59 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)