Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8zmr
Q-score: 0.393
Zhang Y, Dai F, Chen N, Zhou D, Lee CH, Song C, Zhang Y, Zhang Z
Cell Res (2024) 34 pp. 665-668 [ Pubmed: 38862671 DOI: doi:10.1038/s41422-024-00986-5 ]
- Vesamicol (259 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,vesicular acetylcholine transporter,darpinoff7 (112 kDa, Protein from synthetic construct)
- Vacht (60 kDa, Complex from Escherichia coli (strain K12))
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8zms
Q-score: 0.407
Zhang Y, Dai F, Chen N, Zhou D, Lee CH, Song C, Zhang Y, Zhang Z
Cell Res (2024) 34 pp. 665-668 [ DOI: doi:10.1038/s41422-024-00986-5 Pubmed: 38862671 ]
- Acetylcholine (146 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,vesicular acetylcholine transporter,darpinoff7 (112 kDa, Protein from synthetic construct)
- Vacht (60 kDa, Complex from Escherichia coli (strain K12))
Structure of human ADAM17/iRhom2 sheddase complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8snl
Q-score: 0.506
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Disintegrin and metalloproteinase domain-containing protein 17 (93 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human adam17/irhom2 sheddase complex (Complex from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8snm
Q-score: 0.386
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Mature human adam17/irhom2 sheddase complex in complex with adam17 prodomain (Complex from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Disintegrin and metalloproteinase domain-containing protein 17 propeptide (24 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 8snn
Q-score: 0.615
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Mature human adam17/irhom2 sheddase complex, conformation 1 (Complex from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8sno
Q-score: 0.552
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Calcium ion (40 Da, Ligand)
- Mature human adam17/irhom2 sheddase complex, conformation 2 (Complex from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
Cryo-EM structure of the hamster prion 23-144 fibril at pH 3.7
Resolution: 2.88 Å
EM Method: Helical reconstruction
Fitted PDBs: 8wzx
Q-score: 0.609
Lee CH, Saw JE, Chen EH, Wang CH, Uchihashi T, Chen RP
J Mol Biol (2024) 436 pp. 168576-168576 [ Pubmed: 38641239 DOI: doi:10.1016/j.jmb.2024.168576 ]
- Hamster prion 23-144 fibril (Complex from Mesocricetus auratus)
- Major prion protein (12 kDa, Protein from Mesocricetus auratus)
The BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8hii
Q-score: 0.338
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- The bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8hij
Q-score: 0.296
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- The 5-mthf-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- N-[4-({[(6s)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid (459 Da, Ligand)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8hik
Q-score: 0.249
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Thiamine diphosphate (425 Da, Ligand)
- The tpp-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)