Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7kso
Q-score: 0.379
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ DOI: doi:10.1038/s41467-020-20775-z Pubmed: 33514705 ]
- Prc2:ezh1-aebp2-jarid2 (330 kDa, Complex from Homo sapiens)
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM map of PRC2:EZH1-AEBP2
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ DOI: doi:10.1038/s41467-020-20775-z Pubmed: 33514705 ]
- Aebp2 (Protein from Homo sapiens)
- Prc2:ezh1-aebp2 (299 kDa, Complex from Homo sapiens)
- Ezh1 (Protein from Homo sapiens)
- Suz12 (Protein from Homo sapiens)
- Rbap48 (Protein from Homo sapiens)
- Eed (Protein from Homo sapiens)
PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ksr
Q-score: 0.287
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ DOI: doi:10.1038/s41467-020-20775-z Pubmed: 33514705 ]
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Prc2:ezh1_a from a prc2:ezh1 dimer bound to a nucleosome (266 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7ktp
Q-score: 0.207
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Prc2:ezh1_a from a prc2:ezh1 dimer bound to a nucleosome (266 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
Nucleosome from a dimeric PRC2 bound to a nucleosome
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ktq
Q-score: 0.494
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ DOI: doi:10.1038/s41467-020-20775-z Pubmed: 33514705 ]
- Histone h2a (11 kDa, Protein from Xenopus laevis)
- Nucleosome from a prc2:ezh1 dimer bound to a nucleosome (220 kDa, Complex from Xenopus laevis)
- Histone h2b (10 kDa, Protein from Xenopus laevis)
- Histone h4 (8 kDa, Protein from Xenopus laevis)
- Histone h3 (11 kDa, Protein from Xenopus laevis)
- 601 dna (167-mer) (51 kDa, DNA from Homo sapiens)
- 601 dna (167-mer) (51 kDa, DNA from Homo sapiens)
PRC2:EZH1 dimer bound to a nucleosome (composite map)
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ DOI: doi:10.1038/s41467-020-20775-z Pubmed: 33514705 ]
- 167bp dna 601 strand (DNA from Homo sapiens)
- Aebp2 (Protein from Homo sapiens)
- Prc2:ezh1_a from a prc2:ezh1 dimer bound to a nucleosome (266 kDa, Complex from Homo sapiens)
- Histone h3 (Protein from Xenopus laevis)
- Histone h2b (Protein from Xenopus laevis)
- Histone h4 (Protein from Xenopus laevis)
- Ezh1 (Protein from Homo sapiens)
- Suz12 (Protein from Homo sapiens)
- Jarid2 (Protein from Homo sapiens)
- Rbap48 (Protein from Homo sapiens)
- Eed (Protein from Homo sapiens)
- Histone h2a (Protein from Xenopus laevis)