Structure of human ADAM17/iRhom2 sheddase complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8snl
Q-score: 0.506
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Disintegrin and metalloproteinase domain-containing protein 17 (93 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Human adam17/irhom2 sheddase complex (Complex from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8snm
Q-score: 0.386
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Mature human adam17/irhom2 sheddase complex in complex with adam17 prodomain (Complex from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Disintegrin and metalloproteinase domain-containing protein 17 propeptide (24 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 8snn
Q-score: 0.615
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Mature human adam17/irhom2 sheddase complex, conformation 1 (Complex from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8sno
Q-score: 0.552
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ Pubmed: 38781971 DOI: doi:10.1016/j.molcel.2024.04.025 ]
- Calcium ion (40 Da, Ligand)
- Mature human adam17/irhom2 sheddase complex, conformation 2 (Complex from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
Human S1P transporter Spns2 in an inward-facing open conformation (state 1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8ex4
Q-score: 0.558
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing open conformation (state 4)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8ex5
Q-score: 0.422
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an inward-facing open conformation (state 1*)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8ex6
Q-score: 0.485
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 3)
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8ex7
Q-score: 0.458
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 2)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 8ex8
Q-score: 0.35
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Structure of inhibitor 16d-bound SPNS2
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8g92
Q-score: 0.454
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644-2655.e16 [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
- Spns2 in complex with inhibitor 16d (200 kDa, Complex from Homo sapiens)
- 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine (343 Da, Ligand)
- Sphingosine-1-phosphate transporter spns2 (49 kDa, Protein from Homo sapiens)