Structure of human ADAM17/iRhom2 sheddase complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8snl
Q-score: 0.506
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ DOI: doi:10.1016/j.molcel.2024.04.025 Pubmed: 38781971 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Disintegrin and metalloproteinase domain-containing protein 17 (93 kDa, Protein from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Human adam17/irhom2 sheddase complex (Complex from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8snm
Q-score: 0.386
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ DOI: doi:10.1016/j.molcel.2024.04.025 Pubmed: 38781971 ]
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Disintegrin and metalloproteinase domain-containing protein 17 propeptide (24 kDa, Protein from Homo sapiens)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
- Mature human adam17/irhom2 sheddase complex in complex with adam17 prodomain (Complex from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 8snn
Q-score: 0.615
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ DOI: doi:10.1016/j.molcel.2024.04.025 Pubmed: 38781971 ]
- Mature human adam17/irhom2 sheddase complex, conformation 1 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8sno
Q-score: 0.552
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M
Mol Cell (2024) 84 pp. 2152-2165.e5 [ DOI: doi:10.1016/j.molcel.2024.04.025 Pubmed: 38781971 ]
- Mature human adam17/irhom2 sheddase complex, conformation 2 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Inactive rhomboid protein 2 (93 kDa, Protein from Homo sapiens)
- Disintegrin and metalloproteinase domain-containing protein 17 (68 kDa, Protein from Homo sapiens)
Human S1P transporter Spns2 in an inward-facing open conformation (state 1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8ex4
Q-score: 0.558
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an inward-facing open conformation (state 1*)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8ex6
Q-score: 0.485
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8hij
Q-score: 0.296
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- The 5-mthf-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- N-[4-({[(6s)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid (459 Da, Ligand)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8hik
Q-score: 0.249
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Thiamine diphosphate (425 Da, Ligand)
- The tpp-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region
Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region