Structure of Apo Sialin at pH7.5
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8u3d
Q-score: 0.582
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Sialin (55 kDa, Protein from Homo sapiens)
- Structure of apo sialin at ph7.5 (Complex from Homo sapiens)
Structure of Apo Sialin at pH5.0
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8u3e
Q-score: 0.513
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Structure of apo sialin at ph5.0 (Complex from Homo sapiens)
- Sialin (55 kDa, Protein from Homo sapiens)
Structure of Apo Sialin R168K mutant
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8u3f
Q-score: 0.531
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Structure of apo sialin r168k mutant (Complex from Homo sapiens)
- Sialin (55 kDa, Protein from Homo sapiens)
Structure of NAAG-bound Sialin
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 8u3g
Q-score: 0.479
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Acetyl group (44 Da, Ligand)
- Structure of naag-bound sialin (Complex from Homo sapiens)
- Aspartic acid (133 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- Sialin (55 kDa, Protein from Homo sapiens)
Structure of Fmoc-Leu-OH bound Sialin
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8u3h
Q-score: 0.431
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Sialin (55 kDa, Protein from Homo sapiens)
- Structure of fmoc-leu-oh bound sialin (Complex from Homo sapiens)
- Leucine (131 Da, Ligand)
- Fluorenylmethyloxycarbonyl chloride (258 Da, Ligand)
Structure of Apo Sialin S61A mutant
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9ayb
Q-score: 0.519
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun (2024) 15 pp. 4386-4386 [ Pubmed: 38782953 DOI: doi:10.1038/s41467-024-48535-3 ]
- Structure of apo sialin s61a mutant (Complex from Homo sapiens)
- Sialin (55 kDa, Protein from Homo sapiens)
Human L-TGF-beta1 in complex with the anchor protein LRRC33
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7y1r
Q-score: 0.187
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- L-tgf-beta1 in complex with its anchor protein lrrc33 (150 kDa, Complex from Homo sapiens)
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- Transforming growth factor beta activator lrrc33 (72 kDa, Protein from Homo sapiens)
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7y1t
Q-score: 0.428
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- Transforming growth factor beta-1 proprotein (43 kDa, Protein from Homo sapiens)
- Integrin alpha-v (69 kDa, Protein from Homo sapiens)
- Integrin beta-8 (53 kDa, Protein from Homo sapiens)
- Complex of integrin alphav/beta8 and l-tgf-beta1 at a ratio of 1:2 (210 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Complex of integrin alphaV/beta8, L-TGF-beta1, and LRRC33 at a ratio of 2:2:1
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z
Nat Commun (2022) 13 pp. 4988-4988 [ DOI: doi:10.1038/s41467-022-32655-9 Pubmed: 36008481 ]
- Integrin alphav (Protein from Homo sapiens)
- L-tgf-beta1 (Protein from Homo sapiens)
- Lrrc33 (Protein from Homo sapiens)
- Complex of integrin alphav/beta8, l-tgf-beta1, and lrrc33 at a ratio of 2:2:1 (400 kDa, Complex from Homo sapiens)
- Integrin beta8 (Protein from Homo sapiens)
Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 7khr
Q-score: 0.493
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X
Nat Commun (2021) 12 pp. 1782-1782 [ DOI: doi:10.1038/s41467-021-22111-5 Pubmed: 33741963 ]
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Bos taurus)
- V-type proton atpase subunit h (54 kDa, Protein from Bos taurus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Bos taurus)
- Cryo-em structure of bafilomycin a1-bound intact v-atpase from bovine brain (Complex from Bos taurus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Bos taurus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d (28 kDa, Protein from Bos taurus)
- (5r)-2,4-dideoxy-1-c-{(2s,3r,4s)-3-hydroxy-4-[(2r,3s,4e,6e,9r,10s,11r,12e,14z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-d-threo-pentopyranose (622 Da, Ligand)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Bos taurus)
- Renin receptor (39 kDa, Protein from Bos taurus)
- Methyl (3r,6z,10e,14e)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate (534 Da, Ligand)
- V-type proton atpase subunit f (13 kDa, Protein from Bos taurus)
- Oleic acid (282 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit c 1 (44 kDa, Protein from Bos taurus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Bos taurus)
- V-type proton atpase subunit a (96 kDa, Protein from Bos taurus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Bos taurus)
- V-type proton atpase subunit g (13 kDa, Protein from Bos taurus)
- Ribonuclease kappa (11 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)