Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
Lee RG, Rudler DL, Raven SA, Peng L, Chopin A, Moh ESX, McCubbin T, Siira SJ, Fagan SV, DeBono NJ, Stentenbach M, Browne J, Rackham FF, Li J, Simpson KJ, Marcellin E, Packer NH, Reid GE, Padman BS, Rackham O, Filipovska A
Nature cell Biology ()
Image sets:
- AIVE outputs generated from FIB-SEM data of Cal51 wt cells (Sample A).
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 wt cells (Sample A)
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 PEX26ko cells (Sample B)
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 SEC62ko cells (Sample F)
- Unprocessed FIB-SEM slices acquired from Cal51 SEC61A2ko cells (Sample E)
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 GOLGA5ko cells (Sample C)
- AIVE outputs generated from FIB-SEM data of Cal51 SEC62ko cells (Sample F)
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 SEC61A2ko cells (Sample E)
- AIVE outputs generated from FIB-SEM data of Cal51 GOLGA5ko cells (Sample C)
- Preprocessed inputs for AIVE (AI-directed Voxel Extraction) of Cal51 GOLGA8Mko cells (Sample D)
- AIVE outputs generated from FIB-SEM data of Cal51 SEC61A2ko cells (Sample E)
- Unprocessed FIB-SEM slices acquired from Cal51 wt cells (Sample A)
- Unprocessed FIB-SEM slices acquired from Cal51 PEX26ko cells (Sample B)
- Unprocessed FIB-SEM slices acquired from Cal51 GOLGA8Mko cells (Sample D)
- AIVE outputs generated from FIB-SEM data of Cal51 GOLGA8Mko cells (Sample D)
- AIVE outputs generated from FIB-SEM data of Cal51 PEX26ko cells (Sample B)
- Unprocessed FIB-SEM slices acquired from Cal51 SEC62ko cells (Sample F)
- Unprocessed FIB-SEM slices acquired from Cal51 GOLGA5ko cells (Sample C)
55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8oin
Q-score: 0.384
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- Mitochondrial ribosomal protein s11 (20 kDa, Protein from Sus scrofa)
- Ms39 (78 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l40 (19 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ul22m (24 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ml43 (17 kDa, Protein from Sus scrofa)
- N-formylmethionine (177 Da, Ligand)
- Ml42 (16 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l10 (29 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l52, mitochondrial (17 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l46 (32 kDa, Protein from Sus scrofa)
- Ms23 (21 kDa, Protein from Sus scrofa)
- Ml64 (25 kDa, Protein from Sus scrofa)
- Cp phe-trna (23 kDa, RNA from Sus scrofa)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Sus scrofa)
- Ribosomal protein (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l9 (30 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l39 (38 kDa, Protein from Sus scrofa)
- Us9m (45 kDa, Protein from Sus scrofa)
- Ml44 (37 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s17, mitochondrial (14 kDa, Protein from Sus scrofa)
- Small ribosomal subunit protein ms38 (22 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s10 (23 kDa, Protein from Sus scrofa)
- Ul16m (28 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l4 (33 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s12 (15 kDa, Protein from Sus scrofa)
- Spermine (202 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Mitochondrial ribosomal protein s24 (18 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18c (16 kDa, Protein from Sus scrofa)
- Spermidine (145 Da, Ligand)
- Mitochondrial ribosomal protein s34 (55 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s26 (23 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s31, mitochondrial (43 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l27, mitochondrial (15 kDa, Protein from Sus scrofa)
- 12s rrna (308 kDa, RNA from Sus scrofa)
- Mitochondrial ribosomal protein l37 (47 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l55 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l11 (20 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l1, mitochondrial (34 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l12 (21 kDa, Protein from Sus scrofa)
- Ml54 (15 kDa, Protein from Sus scrofa)
- Mitoribosomal protein ms28, mrps28 (21 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s5, mitochondrial isoform x2 (48 kDa, Protein from Sus scrofa)
- E-site trna (894 Da, RNA from Sus scrofa)
- 28s ribosomal protein s35, mitochondrial isoform 1 (41 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s27 (45 kDa, Protein from Sus scrofa)
- 16s rrna (504 kDa, RNA from Sus scrofa)
- Mitochondrial ribosomal protein s2 (31 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Sus scrofa)
- Ml62 (ict1) (23 kDa, Protein from Sus scrofa)
- Water (18 Da, Ligand)
- Mitochondrial ribosomal protein l14 (34 kDa, Protein from Sus scrofa)
- Phenylalanine (165 Da, Ligand)
- Bl17m (19 kDa, Protein from Sus scrofa)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Mitochondrial ribosomal protein l57 (12 kDa, Protein from Sus scrofa)
- Small ribosomal subunit protein ms29 (46 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s25 (19 kDa, Protein from Sus scrofa)
- 55s mammalian mitochondrial ribosome with mtrf1 and p-site trna (2 MDa, Complex from Sus scrofa)
- Mitochondrial ribosomal protein s14 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l47 (29 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l2 (33 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s18b, mitochondrial (29 kDa, Protein from Sus scrofa)
- Mrna (2 kDa, RNA from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial ribosomal protein l38 (44 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l18 (21 kDa, Protein from Sus scrofa)
- P-site met-trna(fmet) (22 kDa, RNA from Homo sapiens)
- 28s ribosomal protein s15, mitochondrial (29 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Mitochondrial ribosomal protein l50 (22 kDa, Protein from Sus scrofa)
- Coiled-coil-helix-coiled-coil-helix domain containing 1 (13 kDa, Protein from Sus scrofa)
- Mitoribosomal protein bs6m, mrps6 (14 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l19, mitochondrial (34 kDa, Protein from Sus scrofa)
- Potassium ion (39 Da, Ligand)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s21, mitochondrial (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s7 (28 kDa, Protein from Sus scrofa)
- Ul24m (24 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Sus scrofa)
- Mrpl34 (18 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l32 (23 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s22 (43 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l28 (30 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l20 (17 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l48, mitochondrial (29 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18a (22 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l13, mitochondrial (22 kDa, Protein from Sus scrofa)
- Peptide chain release factor 1, mitochondrial (55 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l53 (12 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s33 (16 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l21 (23 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s16, mitochondrial (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l45 (35 kDa, Protein from Sus scrofa)
- Ict1 (43 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- 39s ribosomal protein s30, mitochondrial (49 kDa, Protein from Sus scrofa)
39S mammalian mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8oiq
Q-score: 0.44
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- Ul16m (28 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l50 (22 kDa, Protein from Sus scrofa)
- E-site trna (894 Da, RNA from Sus scrofa)
- 39s ribosomal protein l19, mitochondrial (34 kDa, Protein from Sus scrofa)
- 16s rrna (504 kDa, RNA from Sus scrofa)
- Potassium ion (39 Da, Ligand)
- Mitochondrial ribosomal protein l4 (33 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Sus scrofa)
- Ml62 (ict1) (23 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l40 (19 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l49, mitochondrial (18 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ul22m (24 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l14 (34 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ml43 (17 kDa, Protein from Sus scrofa)
- Ul24m (24 kDa, Protein from Sus scrofa)
- Phenylalanine (165 Da, Ligand)
- Large ribosomal subunit protein bl33m (7 kDa, Protein from Sus scrofa)
- N-formylmethionine (177 Da, Ligand)
- Bl17m (19 kDa, Protein from Sus scrofa)
- 39s mammalian mitochondrial ribosome with mtrf1 and p-site trnamet (1 MDa, Complex from Sus scrofa)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Mitochondrial ribosomal protein l57 (12 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l32 (23 kDa, Protein from Sus scrofa)
- Ml42 (16 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l10 (29 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l52, mitochondrial (17 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ml51 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l28 (30 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l20 (17 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l48, mitochondrial (29 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l46 (32 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l27, mitochondrial (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l47 (29 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l2 (33 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18a (22 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l13, mitochondrial (22 kDa, Protein from Sus scrofa)
- Peptide chain release factor 1, mitochondrial (55 kDa, Protein from Homo sapiens)
- Mitochondrial ribosomal protein l53 (12 kDa, Protein from Sus scrofa)
- Ml64 (25 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l37 (47 kDa, Protein from Sus scrofa)
- Cp phe-trna (23 kDa, RNA from Sus scrofa)
- Mitochondrial ribosomal protein l38 (44 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l21 (23 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l18 (21 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l11 (20 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein bl34m (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l55 (15 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l1, mitochondrial (34 kDa, Protein from Sus scrofa)
- Ribosomal protein (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l45 (35 kDa, Protein from Sus scrofa)
- Large ribosomal subunit protein ul30m (18 kDa, Protein from Sus scrofa)
- Ict1 (43 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l12 (21 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l9 (30 kDa, Protein from Sus scrofa)
- Ml54 (15 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein l39 (38 kDa, Protein from Sus scrofa)
- P-site met-trna(fmet) (22 kDa, RNA from Homo sapiens)
- Ml44 (37 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein s30, mitochondrial (49 kDa, Protein from Sus scrofa)
55S human mitochondrial ribosome with mtRF1 and P-site tRNA
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8oir
Q-score: 0.434
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s5, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s28, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s26, mitochondrial (24 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s34, mitochondrial (25 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- 28s ribosomal protein s10, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s23, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- E-site trna (894 Da, RNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s31, mitochondrial (45 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s35, mitochondrial (36 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s17, mitochondrial (14 kDa, Protein from Homo sapiens)
- Pentatricopeptide repeat domain-containing protein 3, mitochondrial (78 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s9, mitochondrial (45 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l1, mitochondrial (36 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s15, mitochondrial (29 kDa, Protein from Homo sapiens)
- Aurora kinase a-interacting protein (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 28s ribosomal protein s12, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 55s human mitochondrial ribosome with mtrf1 and p-site trna (50 kDa, Complex from Homo sapiens)
- 28s ribosomal protein s25, mitochondrial (20 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s18b, mitochondrial (29 kDa, Protein from Homo sapiens)
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 (13 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s7, mitochondrial (28 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s33, mitochondrial (12 kDa, Protein from Homo sapiens)
- Peptide chain release factor 1, mitochondrial (56 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s18c, mitochondrial (15 kDa, Protein from Homo sapiens)
- P-site met-trna(met) (22 kDa, RNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l12, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- Mrna (7 kDa, RNA from Homo sapiens)
- Cp val-trna(val) (22 kDa, RNA from Homo sapiens)
- 28s ribosomal protein s29, mitochondrial (45 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s24, mitochondrial (19 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Valine (117 Da, Ligand)
- 28s ribosomal protein s6, mitochondrial (14 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s21, mitochondrial (10 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s27, mitochondrial (47 kDa, Protein from Homo sapiens)
- Fe-s-o hybrid cluster (335 Da, Ligand)
- 28s ribosomal protein s22, mitochondrial (41 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s16, mitochondrial (15 kDa, Protein from Homo sapiens)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- 28s ribosomal protein s14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ois
Q-score: 0.454
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s27, mitochondrial (47 kDa, Protein from Homo sapiens)
- Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 (13 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- 28s ribosomal protein s18c, mitochondrial (15 kDa, Protein from Homo sapiens)
- Aurora kinase a-interacting protein (22 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s15, mitochondrial (29 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s16, mitochondrial (15 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s25, mitochondrial (20 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- 28s ribosomal protein s2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s12, mitochondrial (15 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s28, mitochondrial (20 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s18b, mitochondrial (29 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- P-site met-trna(met) (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 28s ribosomal protein s14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s31, mitochondrial (45 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 28s ribosomal protein s33, mitochondrial (12 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s7, mitochondrial (28 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s5, mitochondrial (48 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s34, mitochondrial (25 kDa, Protein from Homo sapiens)
- 28s human mitochondrial small ribosomal subunit with mtrf1, mrna, and p-site trna (50 kDa, Complex from Homo sapiens)
- 28s ribosomal protein s23, mitochondrial (21 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s22, mitochondrial (41 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s9, mitochondrial (45 kDa, Protein from Homo sapiens)
- Mrna (7 kDa, RNA from Homo sapiens)
- 28s ribosomal protein s26, mitochondrial (24 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s6, mitochondrial (14 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s21, mitochondrial (10 kDa, Protein from Homo sapiens)
- Peptide chain release factor 1, mitochondrial,mtrf1(aaq) (56 kDa, Protein from Homo sapiens)
- 12s rrna (306 kDa, RNA from Homo sapiens)
- 28s ribosomal protein s10, mitochondrial (23 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- 28s ribosomal protein s24, mitochondrial (19 kDa, Protein from Homo sapiens)
- Fe-s-o hybrid cluster (335 Da, Ligand)
- 28s ribosomal protein s17, mitochondrial (14 kDa, Protein from Homo sapiens)
- Pentatricopeptide repeat domain-containing protein 3, mitochondrial (78 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s29, mitochondrial (45 kDa, Protein from Homo sapiens)
- 28s ribosomal protein s35, mitochondrial (36 kDa, Protein from Homo sapiens)
39S human mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8oit
Q-score: 0.491
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- 39s ribosomal protein l12, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- Cp val-trna(val) (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- Valine (117 Da, Ligand)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- E-site trna (894 Da, RNA from Homo sapiens)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ml43 (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- Methionine (149 Da, Ligand)
- Fe-s-o hybrid cluster (335 Da, Ligand)
- 16s rrna (500 kDa, RNA from Homo sapiens)
- 39s human mitochondrial ribosome with mtrf1 and p-site trna (50 kDa, Complex from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- Peptide chain release factor 1, mitochondrial (56 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- P-site met-trna(met) (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l1, mitochondrial (36 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
28S mammalian mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8oip
Q-score: 0.418
Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schonhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarcic T, Kummer E, Gatfield D, Filipovska A, Ban N
Science (2023) 380 pp. 531-536 [ Pubmed: 37141370 DOI: doi:10.1126/science.adf9890 ]
- Mitochondrial ribosomal protein s11 (20 kDa, Protein from Sus scrofa)
- Coiled-coil-helix-coiled-coil-helix domain containing 1 (13 kDa, Protein from Sus scrofa)
- Ms39 (78 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s35, mitochondrial isoform 1 (41 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s27 (45 kDa, Protein from Sus scrofa)
- 39s ribosomal protein l19, mitochondrial (34 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s2 (31 kDa, Protein from Sus scrofa)
- Us17m (14 kDa, Protein from Sus scrofa)
- Potassium ion (39 Da, Ligand)
- 28s ribosomal protein s21, mitochondrial (10 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s12 (15 kDa, Protein from Sus scrofa)
- Spermine (202 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Mitochondrial ribosomal protein s7 (28 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s24 (18 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s18c (16 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s34 (55 kDa, Protein from Sus scrofa)
- Spermidine (145 Da, Ligand)
- Aurora kinase a interacting protein 1 (22 kDa, Protein from Sus scrofa)
- P-site met-trna(fmet) (22 kDa, RNA from Homo sapiens)
- 12s rrna (309 kDa, RNA from Sus scrofa)
- Mitochondrial ribosomal protein s26 (23 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s25 (19 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s22 (43 kDa, Protein from Sus scrofa)
- Fe-s-o hybrid cluster (335 Da, Ligand)
- Bl31m (15 kDa, Protein from Sus scrofa)
- 28s mammalian mitochondrial small ribosomal subunit with mtrf1, mrna, and p-site trna (1 MDa, Complex from Sus scrofa)
- Ms23 (21 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s31, mitochondrial (43 kDa, Protein from Sus scrofa)
- Mitochondrial ribosomal protein s14 (15 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s18b, mitochondrial (29 kDa, Protein from Sus scrofa)
- Peptide chain release factor 1, mitochondrial (55 kDa, Protein from Homo sapiens)
- Mrna (2 kDa, RNA from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial ribosomal protein s33 (16 kDa, Protein from Sus scrofa)
- Bs6m,mitochondrial ribosomal protein s6 (41 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s16, mitochondrial (15 kDa, Protein from Sus scrofa)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Mitoribosomal protein ms28, mrps28 (21 kDa, Protein from Sus scrofa)
- Us9m (45 kDa, Protein from Sus scrofa)
- Death associated protein 3 (46 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s15, mitochondrial (29 kDa, Protein from Sus scrofa)
- 28s ribosomal protein s5, mitochondrial isoform x2 (48 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Mitochondrial ribosomal protein s10 (23 kDa, Protein from Sus scrofa)
State A of the human mitoribosomal large subunit assembly intermediate
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7odr
Q-score: 0.473
Lenarcic T, Jaskolowski M, Leibundgut M, Scaiola A, Schonhut T, Saurer M, Lee RG, Rackham O, Filipovska A, Ban N
Nat Commun (2021) 12 pp. 3671-3671 [ DOI: doi:10.1038/s41467-021-23811-8 Pubmed: 34135320 ]
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- 16s mitochondrial rrna, dna (31-mer),16s mitochondrial rrna (506 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Transcription termination factor 4, mitochondrial (44 kDa, Protein from Homo sapiens)
- 5-methylcytosine rrna methyltransferase nsun4 (43 kDa, Protein from Homo sapiens)
- State a of the human mitoribosomal large subunit assembly intermediate (Complex from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l43, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- Mief1 upstream open reading frame protein (8 kDa, Protein from Homo sapiens)
- S-(2-{[n-(2-hydroxy-4-{[hydroxy(oxido)phosphino]oxy}-3,3-dimethylbutanoyl)-beta-alanyl]amino}ethyl) decanethioate (496 Da, Ligand)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mitochondrial trnaval (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
State B of the human mitoribosomal large subunit assembly intermediate
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ods
Q-score: 0.425
Lenarcic T, Jaskolowski M, Leibundgut M, Scaiola A, Schonhut T, Saurer M, Lee RG, Rackham O, Filipovska A, Ban N
Nat Commun (2021) 12 pp. 3671-3671 [ Pubmed: 34135320 DOI: doi:10.1038/s41467-021-23811-8 ]
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- Any 5'-monophosphate nucleotide (214 Da, Ligand)
- State b of the human mitoribosomal large subunit assembly intermediate (Complex from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- Transcription termination factor 4, mitochondrial (44 kDa, Protein from Homo sapiens)
- Mief1 upstream open reading frame protein (8 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- Mitochondrial trnaval (22 kDa, RNA from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 16s mitochondrial rrna, dna (30-mer),16s mitochondrial rrna (505 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- S-(2-{[n-(2-hydroxy-4-{[hydroxy(oxido)phosphino]oxy}-3,3-dimethylbutanoyl)-beta-alanyl]amino}ethyl) decanethioate (496 Da, Ligand)
- 5-methylcytosine rrna methyltransferase nsun4 (43 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l43, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- Rrna methyltransferase 2, mitochondrial (27 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
State C of the human mitoribosomal large subunit assembly intermediate
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7odt
Q-score: 0.43
Lenarcic T, Jaskolowski M, Leibundgut M, Scaiola A, Schonhut T, Saurer M, Lee RG, Rackham O, Filipovska A, Ban N
Nat Commun (2021) 12 pp. 3671-3671 [ DOI: doi:10.1038/s41467-021-23811-8 Pubmed: 34135320 ]
- 39s ribosomal protein l21, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l49, mitochondrial (19 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s18a, mitochondrial (22 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l54, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l39, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l52, mitochondrial (13 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l51, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l2, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l32, mitochondrial (21 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Mitochondrial ribosome-associated gtpase 2 (44 kDa, Protein from Homo sapiens)
- Mitochondrial assembly of ribosomal large subunit protein 1 (26 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l23, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l24, mitochondrial (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 39s ribosomal protein l36, mitochondrial (11 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l15, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l42, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l40, mitochondrial (24 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l4, mitochondrial (34 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l44, mitochondrial (37 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l10, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l13, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l28, mitochondrial (30 kDa, Protein from Homo sapiens)
- State c of the human mitoribosomal large subunit assembly intermediate (Complex from Homo sapiens)
- 39s ribosomal protein l9, mitochondrial (30 kDa, Protein from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- 39s ribosomal protein l18, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l53, mitochondrial (12 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l47, mitochondrial (29 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l48, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l46, mitochondrial (31 kDa, Protein from Homo sapiens)
- Fe2/s2 (inorganic) cluster (175 Da, Ligand)
- Transcription termination factor 4, mitochondrial (44 kDa, Protein from Homo sapiens)
- 5-methylcytosine rrna methyltransferase nsun4 (43 kDa, Protein from Homo sapiens)
- 16s mitochondrial rrna (500 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l35, mitochondrial (21 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l37, mitochondrial (48 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l55, mitochondrial (15 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l3, mitochondrial (38 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l34, mitochondrial (10 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l11, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l20, mitochondrial (17 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l38, mitochondrial (44 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l17, mitochondrial (20 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l45, mitochondrial (35 kDa, Protein from Homo sapiens)
- Growth arrest and dna damage-inducible proteins-interacting protein 1 (25 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l22, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l27, mitochondrial (16 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l33, mitochondrial (7 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l43, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein s30, mitochondrial (50 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l30, mitochondrial (18 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Acyl carrier protein, mitochondrial (17 kDa, Protein from Homo sapiens)
- Mief1 upstream open reading frame protein (8 kDa, Protein from Homo sapiens)
- S-(2-{[n-(2-hydroxy-4-{[hydroxy(oxido)phosphino]oxy}-3,3-dimethylbutanoyl)-beta-alanyl]amino}ethyl) decanethioate (496 Da, Ligand)
- 39s ribosomal protein l19, mitochondrial (33 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l41, mitochondrial (15 kDa, Protein from Homo sapiens)
- Peptidyl-trna hydrolase ict1, mitochondrial (23 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l14, mitochondrial (15 kDa, Protein from Homo sapiens)
- Ribosomal protein 63, mitochondrial (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Mitochondrial trnaval (22 kDa, RNA from Homo sapiens)
- 39s ribosomal protein l50, mitochondrial (18 kDa, Protein from Homo sapiens)
- 39s ribosomal protein l16, mitochondrial (28 kDa, Protein from Homo sapiens)