Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8piu
Q-score: 0.574
Zdanowicz R, Afanasyev P, Pruska A, Harrison JA, Giese C, Boehringer D, Leitner A, Zenobi R, Glockshuber R
Sci Adv (2024) 10 pp. eadn4582-eadn4582 [ Pubmed: 39018392 DOI: doi:10.1126/sciadv.adn4582 ]
Zdanowicz R, Afanasyev P, Pruska A, Harrison JA, Giese C, Boehringer D, Leitner A, Zenobi R, Glockshuber R
Sci Adv (2024) 10 pp. eadn4582-eadn4582 [ Pubmed: 39018392 DOI: doi:10.1126/sciadv.adn4582 ]
E2/E3BP core of the human pyruvate dehydrogenase complex (map 1; 3.4 A)
Zdanowicz R, Afanasyev P, Pruska A, Harrison JA, Giese C, Boehringer D, Leitner A, Zenobi R, Glockshuber R
Sci Adv (2024) 10 pp. eadn4582-eadn4582 [ Pubmed: 39018392 DOI: doi:10.1126/sciadv.adn4582 ]
E2/E3BP core of the human pyruvate dehydrogenase complex (map 2; 3.7 A)
Zdanowicz R, Afanasyev P, Pruska A, Harrison JA, Giese C, Boehringer D, Leitner A, Zenobi R, Glockshuber R
Sci Adv (2024) 10 pp. eadn4582-eadn4582 [ Pubmed: 39018392 DOI: doi:10.1126/sciadv.adn4582 ]
TRiC-substrate complex in ATP/AlFx closed state
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7lum
Q-score: 0.291
Knowlton JJ, Gestaut D, Ma B, Taylor G, Seven AB, Leitner A, Wilson GJ, Shanker S, Yates NA, Prasad BVV, Aebersold R, Chiu W, Frydman J, Dermody TS
PNAS (2021) 118 [ Pubmed: 33836586 DOI: doi:10.1073/pnas.2018127118 ]
- Human tric/cct complex (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
Human TRiC/CCT complex with reovirus outer capsid protein sigma-3
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 7lup
Q-score: 0.217
Knowlton JJ, Gestaut D, Ma B, Taylor G, Seven AB, Leitner A, Wilson GJ, Shanker S, Yates NA, Prasad BVV, Aebersold R, Chiu W, Frydman J, Dermody TS
PNAS (2021) 118 [ Pubmed: 33836586 DOI: doi:10.1073/pnas.2018127118 ]
- Human tric/cct complex with reovirus outer capsid protein sigma-3 (41 MDa, Complex)
- Zinc ion (65 Da, Ligand)
- Reovirus outer capsid protein sigma-3 (Complex from Mammalian orthoreovirus 3 Dearing)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Outer capsid protein sigma-3 (41 kDa, Protein from Reovirus type 3 (strain Dearing))
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM structure of the Full-length disease type human Huntingtin
Resolution: 18.2 Å
EM Method: Single-particle
Fitted PDBs: 6yej
Q-score: 0.036
Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ
Structure (2020) 28 pp. 1035-1050.e8 [ DOI: doi:10.1016/j.str.2020.06.008 Pubmed: 32668197 ]
- Huntingtin (355 kDa, Protein from Homo sapiens)
- Full-length human disease-type huntingtin (350 kDa, Cellular component from Homo sapiens)
Radial spoke head structure with 2-fold symmetization
Poghosyan E, Iacovache I, Faltova L, Leitner A, Yang P, Diener DR, Aebersold R, Zuber B, Ishikawa T
J Cell Sci (2020) 133 [ DOI: doi:10.1242/jcs.245233 Pubmed: 32694165 ]
- Radial spoke of cilia (1 MDa, Complex from Chlamydomonas reinhardtii)
Radial spoke from cilia (before symmetrization)
Poghosyan E, Iacovache I, Faltova L, Leitner A, Yang P, Diener DR, Aebersold R, Zuber B, Ishikawa T
J Cell Sci (2020) 133 [ DOI: doi:10.1242/jcs.245233 Pubmed: 32694165 ]
- Radial spoke of cilia (1 MDa, Complex from Chlamydomonas reinhardtii)
Cryo-EM 3D map of normal Huntingtin
Resolution: 9.6 Å
EM Method: Single-particle
Fitted PDBs: 6rmh
Q-score: 0.026
Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ
Structure (2020) 28 pp. 1035-1050.e8 [ DOI: doi:10.1016/j.str.2020.06.008 Pubmed: 32668197 ]
- Normal-type human huntingtin (350 kDa, Cellular component from Homo sapiens)
- Huntingtin (347 kDa, Protein from Homo sapiens)