TRiC-substrate complex in ATP/AlFx closed state
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7lum
Q-score: 0.291
Knowlton JJ, Gestaut D, Ma B, Taylor G, Seven AB, Leitner A, Wilson GJ, Shanker S, Yates NA, Prasad BVV, Aebersold R, Chiu W, Frydman J, Dermody TS
PNAS (2021) 118 [ Pubmed: 33836586 DOI: doi:10.1073/pnas.2018127118 ]
- Human tric/cct complex (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
Human TRiC/CCT complex with reovirus outer capsid protein sigma-3
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 7lup
Q-score: 0.217
Knowlton JJ, Gestaut D, Ma B, Taylor G, Seven AB, Leitner A, Wilson GJ, Shanker S, Yates NA, Prasad BVV, Aebersold R, Chiu W, Frydman J, Dermody TS
PNAS (2021) 118 [ Pubmed: 33836586 DOI: doi:10.1073/pnas.2018127118 ]
- Human tric/cct complex with reovirus outer capsid protein sigma-3 (41 MDa, Complex)
- Zinc ion (65 Da, Ligand)
- Reovirus outer capsid protein sigma-3 (Complex from Mammalian orthoreovirus 3 Dearing)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- Outer capsid protein sigma-3 (41 kDa, Protein from Reovirus type 3 (strain Dearing))
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 6nr8
Q-score: 0.137
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (11 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (15 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 5 (14 kDa, Protein from Homo sapiens)
- Htric-hpfd (Complex from Homo sapiens)
- Prefoldin subunit 4 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- Hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
- Prefoldin subunit 6 (11 kDa, Protein from Homo sapiens)
Resolution: 8.5 Å
EM Method: Single-particle
Fitted PDBs: 6nr9
Q-score: 0.111
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (11 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (15 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (12 kDa, Protein from Homo sapiens)
- Prefoldin subunit 5 (14 kDa, Protein from Homo sapiens)
- Htric-hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 4 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- Hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
- Prefoldin subunit 6 (11 kDa, Protein from Homo sapiens)
Resolution: 7.7 Å
EM Method: Single-particle
Fitted PDBs: 6nra
Q-score: 0.101
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
Resolution: 8.7 Å
EM Method: Single-particle
Fitted PDBs: 6nrb
Q-score: 0.109
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (11 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (15 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (12 kDa, Protein from Homo sapiens)
- Prefoldin subunit 5 (14 kDa, Protein from Homo sapiens)
- Htric-hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 4 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- Hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
- Prefoldin subunit 6 (11 kDa, Protein from Homo sapiens)
Resolution: 8.3 Å
EM Method: Single-particle
Fitted PDBs: 6nrc
Q-score: 0.112
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (11 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (15 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 5 (14 kDa, Protein from Homo sapiens)
- Htric-hpfd (Complex from Homo sapiens)
- Prefoldin subunit 4 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- Hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
- Prefoldin subunit 6 (11 kDa, Protein from Homo sapiens)
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6nrd
Q-score: 0.111
Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J
Cell (2019) 177 pp. 751-765.e15 [ DOI: doi:10.1016/j.cell.2019.03.012 Pubmed: 30955883 ]
- T-complex protein 1 subunit theta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 2 (11 kDa, Protein from Homo sapiens)
- Prefoldin subunit 3 (15 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (58 kDa, Protein from Homo sapiens)
- Prefoldin subunit 1 (12 kDa, Protein from Homo sapiens)
- Prefoldin subunit 5 (14 kDa, Protein from Homo sapiens)
- Htric-hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit delta (55 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit zeta (56 kDa, Protein from Homo sapiens)
- Prefoldin subunit 4 (12 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (57 kDa, Protein from Homo sapiens)
- Hpfd (Complex from Homo sapiens)
- T-complex protein 1 subunit eta (56 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (54 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (56 kDa, Protein from Homo sapiens)
- Htric (Complex from Homo sapiens)
- Prefoldin subunit 6 (11 kDa, Protein from Homo sapiens)
Human cap-dependent 48S pre-initiation complex
Resolution: 6.3 Å
EM Method: Single-particle
Fitted PDBs: 6fec
Q-score: 0.116
Eliseev B, Yeramala L, Leitner A, Karuppasamy M, Raimondeau E, Huard K, Alkalaeva E, Aebersold R, Schaffitzel C
Nucleic Acids Res (2018) 46 pp. 2678-2689 [ DOI: doi:10.1093/nar/gky054 Pubmed: 29401259 ]
- 40s ribosomal protein s10 (11 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit l (66 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (23 kDa, Protein from Homo sapiens)
- Ubiquitin-40s ribosomal protein s27a (8 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit c (97 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit b (124 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (8 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit k (25 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit m (42 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (21 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (45 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (25 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (27 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 beta subunit (eif2-beta) (2 kDa, Protein from Homo sapiens)
- Mrna (Complex from Homo sapiens)
- Transfer rna (75-mer) (24 kDa, RNA from Homo sapiens)
- 18s ribosomal rna (572 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s3a (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s12 (13 kDa, Protein from Homo sapiens)
- Messenger rna (26-mer) (8 kDa, RNA from Homo sapiens)
- Eukaryotic translation initiation factor 4b (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- 40s ribosomal protein s2 (24 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 4b (72 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (15 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit e (52 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (11 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (11 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit h (39 kDa, Protein from Homo sapiens)
- Human cap-dependent 48s translation pre-initiation complex (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit f (37 kDa, Protein from Homo sapiens)
- Human cap-dependent 48s translation pre-initiation complex (2 MDa, Complex)
- 40s ribosomal protein s18 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (8 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (34 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit a (164 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (21 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 3 subunit d (42 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
The human 26S Proteasome at 6.8 Ang.
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 5ln3
Q-score: 0.141
Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L
Mol Cell Proteomics (2017) 16 pp. 840-854 [ DOI: doi:10.1074/mcp.M116.065326 Pubmed: 28292943 ]
- 26s proteasome non-atpase regulatory subunit 8 (39 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 3 (61 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 12 (52 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Human 26s proteasome (2 MDa, Complex from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 4 (49 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 10b (44 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6b (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 6 (45 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 1 (105 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 14 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 2 (100 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 13 (42 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 8 (45 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 6a (49 kDa, Protein from Homo sapiens)
- 26s protease regulatory subunit 7 (48 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 11 (47 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 7 (37 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- 26s proteasome complex subunit dss1 (8 kDa, Protein from Homo sapiens)
- 26s proteasome non-atpase regulatory subunit 4 (40 kDa, Protein from Homo sapiens)