Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xyd
Q-score: 0.366
Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y
Cell Rep (2024) 43 pp. 114422-114422 [ Pubmed: 38943642 DOI: doi:10.1016/j.celrep.2024.114422 ]
- Platelet-activating factor receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ptafr-paf g protein complex (Complex from Homo sapiens)
- (2r)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate (523 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of prolactin-releasing peptide recognition with Gi
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8zps
Q-score: 0.406
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Molecular mechanism of prolactin-releasing peptide recognition with gi (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
Cryo-EM structure of prolactin-releasing peptide recognition with Gq
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8zpt
Q-score: 0.432
Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH
Cell Discov (2024) 10 pp. 91-91 [ DOI: doi:10.1038/s41421-024-00724-6 Pubmed: 39223120 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Molecular mechanism of prolactin-releasing peptide recognition with gq (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(324) subunit alpha-1, (41 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide receptor (41 kDa, Protein from Homo sapiens)
- Prolactin-releasing peptide prrp20 (2 kDa, Protein from Homo sapiens)
Cryo-EM structure of the BA1-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- Ba1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ba1-brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the MK-5046-bound BRS3-Gq complex
Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W
Cell Rep (2024) 43 pp. 114511-114511 [ DOI: doi:10.1016/j.celrep.2024.114511 Pubmed: 39024101 ]
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Bombesin receptor subtype-3 (40 kDa, Protein from Homo sapiens)
- (2~{s})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{h}-imidazol-2-yl]propan-2-ol (444 Da, Ligand)
- Mk-5046-brs3-gq complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Scfv16 (26 kDa, Protein from Mus musculus)
Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8x8l
Q-score: 0.493
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ DOI: doi:10.1073/pnas.2321710121 Pubmed: 38885377 ]
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cortistatin (2 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Cortistatin 17-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x8n
Q-score: 0.483
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ Pubmed: 38885377 DOI: doi:10.1073/pnas.2321710121 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor SUCR1 bound to compound 31
Resolution: 2.48 Å
EM Method: Single-particle
Fitted PDBs: 8ykv
Q-score: 0.585
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ Pubmed: 38834763 DOI: doi:10.1038/s41422-024-00984-7 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- (2~{s})-2-[[6-[4-(trifluoromethyloxy)phenyl]pyridin-2-yl]carbonylamino]butanedioic acid (398 Da, Ligand)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ykw
Q-score: 0.553
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ Pubmed: 38834763 DOI: doi:10.1038/s41422-024-00984-7 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ykx
Q-score: 0.563
Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE
Cell Res (2024) 34 pp. 594-596 [ Pubmed: 38834763 DOI: doi:10.1038/s41422-024-00984-7 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of succinate receptor sucr1 bound to succinic acid (160 kDa, Complex from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from synthetic construct)
- Maleic acid (116 Da, Ligand)
- Succinate receptor 1 (38 kDa, Protein from Homo sapiens)