BA.2.86 RBD protein in complex with ACE2.
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8yzb
Q-score: 0.477
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
- Ba.2.86 rbd protein in complex with ace2 (Complex from Homo sapiens)
- Spike glycoprotein,fibritin,fusion protein (142 kDa, Protein from synthetic construct)
- Angiotensin-converting enzyme 2 (85 kDa, Protein from Homo sapiens)
Structure of JN.1 RBD protein in complex with ACE2.
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8yzd
Q-score: 0.573
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
The JN.1 spike protein (S) in complex with ACE2.
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8yze
Q-score: 0.25
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ DOI: doi:10.1038/s41467-024-53033-7 Pubmed: 39379369 ]
cryo-EM structure of human Cereblon/DDB1 in complex with a non-traditional CRBN binder
Lejava A, Miseo GA, Phan T, Zhu J, Powers HL, Li J, Mortensen DS, Zapf CW, Khambatta G, Buenviaje J, Holmberg-Douglas N
Acs Med.Chem.Lett. (2025) 16 pp. 89-95 [ Pubmed: 39811117 DOI: doi:10.1021/acsmedchemlett.4c00462 ]
- Protein cereblon (53 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Crebn-ddb1 plus a non-traditional crbn binder (Complex from Homo sapiens)
- (3r)-3-{1-methyl-6-[(piperidin-4-yl)amino]-1h-indazol-3-yl}piperidine-2,6-dione (341 Da, Ligand)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8yvc
Q-score: 0.533
Wang P, Li J, Li T, Li K, Ng PC, Wang S, Chriscoli V, Basle A, Marles-Wright J, Zhang YZ, Liu LN
Sci Adv (2024) 10 pp. eadr4227-eadr4227 [ DOI: doi:10.1126/sciadv.adr4227 Pubmed: 39612341 ]
- Carboxysome assembly protein csos2b (29 kDa, Protein from Halothiobacillus neapolitanus)
- Carboxysome shell vertex protein csos4a (8 kDa, Protein from Halothiobacillus neapolitanus)
- Carboxysomal midi-shell:icosahedral assembly from csos4a/4b/1a/1b/1c/1d and csos2 c-terminal co-expression (t = 19) (Complex from Halothiobacillus neapolitanus)
- Major carboxysome shell protein csos1a (9 kDa, Protein from Halothiobacillus neapolitanus)
Cryo-EM structure of the GLP-1(9-36)-bound human GLP-1R-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ivg
Q-score: 0.48
Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW
Acta Pharm Sin B (2024) 14 pp. 5069-5073 [ DOI: doi:10.1016/j.apsb.2024.09.002 Pubmed: 39664415 ]
- Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glp-1(9-36) (3 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from Homo sapiens)
SARS-CoV-2 S + S2L20 (local refinement of NTD and S2L20 Fab variable region)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9c45
Q-score: 0.552
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ DOI: doi:10.1038/s41586-024-08121-5 Pubmed: 39478224 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9axl
Q-score: 0.473
Wang L, Wang J, Li J, Walz T, Coller BS
Blood Adv (2024) 8 pp. 4398-4409 [ Pubmed: 38968144 DOI: doi:10.1182/bloodadvances.2024013177 ]
- Magnesium ion (24 Da, Ligand)
- R21d10 fab heavy chain (24 kDa, Protein from Mus musculus)
- Integrin alpha-iib (113 kDa, Protein from Homo sapiens)
- The semi-extended alphaiibbeta3 in complex with r21d10 fab (250 kDa, Complex)
- R21d10 fab light chain (23 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Integrin beta-3 (87 kDa, Protein from Homo sapiens)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8zre
Q-score: 0.206
Yan H, Liu C, Li Y, Tang S, Guo H, Zhou B, Fan Q, Wang H, Ge X, Wang X, Liao X, Li J, Zhang Z, Ju B
J Virol (2024) pp. e0169424-e0169424 [ Pubmed: 39601613 DOI: doi:10.1128/jvi.01694-24 ]
- Complex of hbv capsid and d4 fab (Complex from hepatitis B virus genotype C)
- Light chains of d4 fab (12 kDa, Protein from Homo sapiens)
- Capsid protein (16 kDa, Protein from hepatitis B virus genotype C)
- Heavy chains of d4 fab (13 kDa, Protein from Homo sapiens)