Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8j6l
Q-score: 0.4
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Svf16 (26 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpb
Q-score: 0.448
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Ntsr1-grk2-galpha(q) complexes 1 (Complex from Homo sapiens)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpc
Q-score: 0.458
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Ntsr1-grk2-galpha(q) complexes 2 (Complex from Homo sapiens)
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8jpf
Q-score: 0.479
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Focused refiment structure of ntsr1 in ntsr1-grk2-galpha(q) complexes (Complex from Homo sapiens)
- Nts (819 Da, Protein from synthetic construct)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
CryoEM structure of full length mouse TRPML2
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7dys
Q-score: 0.438
Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y, Duan J, Zhang J
J Biol Chem (2022) 298 pp. 101487-101487 [ Pubmed: 34915027 DOI: doi:10.1016/j.jbc.2021.101487 ]
- Trpml2 (Cellular component from Mus musculus)
- Mucolipin-2 (60 kDa, Protein from Mus musculus)
Structure of the mouse TRPC4 ion channel
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 6jzo
Q-score: 0.499
Duan J, Li J, Zeng B, Chen G, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J
To Be Published
- Sodium ion (22 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Short transient receptor potential channel 4 (87 kDa, Protein from Mus musculus)
- Mouse trpc4 (Complex from Mus musculus)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
3.7 angstrom cryoEM structure of full length human TRPM4
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6bwi
Q-score: 0.414
Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE
PNAS (2018) 115 pp. 2377-2382 [ Pubmed: 29463718 DOI: doi:10.1073/pnas.1722038115 ]
- Sodium ion (22 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (104 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human full length trpm4 (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
3.3 angstrom structure of mouse TRPM7 with EDTA
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 5zx5
Q-score: 0.511
Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE
PNAS (2018) 115 pp. E8201-E8210 [ DOI: doi:10.1073/pnas.1810719115 Pubmed: 30108148 ]
3.7 angstrom cryoEM structure of truncated mouse TRPM7
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6bwd
Q-score: 0.418
Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE
PNAS (2018) 115 pp. E8201-E8210 [ DOI: doi:10.1073/pnas.1810719115 Pubmed: 30108148 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 7 (107 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Truncated mouse trpm7 with mg2+ (Complex from Mus musculus)