Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8j6l
Q-score: 0.4
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Svf16 (26 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpb
Q-score: 0.448
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ DOI: doi:10.1038/s41586-023-06395-9 Pubmed: 37532940 ]
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Ntsr1-grk2-galpha(q) complexes 1 (Complex from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpc
Q-score: 0.458
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ DOI: doi:10.1038/s41586-023-06395-9 Pubmed: 37532940 ]
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Ntsr1-grk2-galpha(q) complexes 2 (Complex from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8jpf
Q-score: 0.479
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ DOI: doi:10.1038/s41586-023-06395-9 Pubmed: 37532940 ]
- Focused refiment structure of ntsr1 in ntsr1-grk2-galpha(q) complexes (Complex from Homo sapiens)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Nts (819 Da, Protein from synthetic construct)
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
CryoEM structure of full length mouse TRPML2
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7dys
Q-score: 0.438
Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y, Duan J, Zhang J
J Biol Chem (2022) 298 pp. 101487-101487 [ Pubmed: 34915027 DOI: doi:10.1016/j.jbc.2021.101487 ]
- Trpml2 (Cellular component from Mus musculus)
- Mucolipin-2 (60 kDa, Protein from Mus musculus)
3.7 angstrom cryoEM structure of full length human TRPM4
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6bwi
Q-score: 0.414
Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE
PNAS (2018) 115 pp. 2377-2382 [ DOI: doi:10.1073/pnas.1722038115 Pubmed: 29463718 ]
- Transient receptor potential cation channel subfamily m member 4 (104 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human full length trpm4 (Complex from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium ion (22 Da, Ligand)