Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8h8e
Q-score: 0.368
Structure of Xenopus tropicalis acid-sensitive outwardly rectifying channel ASOR (resting state)
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8h8f
Q-score: 0.391
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1j
Q-score: 0.489
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8k1q
Q-score: 0.41
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8k1v
Q-score: 0.422
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8k1z
Q-score: 0.42
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ DOI: doi:10.1073/pnas.2320345121 Pubmed: 38630723 ]
- Potassium ion (39 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Chs (Complex from Homo sapiens)
human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ Pubmed: 38167918 DOI: doi:10.1038/s41589-023-01515-y ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
p53-bound TFIID-based holo PIC on HDM2 promoter
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7egc
Q-score: 0.051
Chen X, Qi Y, Wu Z, Wang X, Li J, Zhao D, Hou H, Li Y, Yu Z, Liu W, Wang M, Ren Y, Li Z, Yang H, Xu Y
Science (2021) 372 [ Pubmed: 33795473 DOI: doi:10.1126/science.aba8490 ]
- Tfiih (Complex)
- Transcription initiation factor iie subunit beta (33 kDa, Protein from Homo sapiens)
- Tfiib (Complex from Homo sapiens)
- General transcription factor iih subunit 2 (44 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 5 (86 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- Dna(hdm2 promoters) (Complex)
- Dna-directed rna polymerase ii subunit rpb4 (16 kDa, Protein from Sus scrofa)
- General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- General transcription and dna repair factor iih helicase subunit xpb (89 kDa, Protein from Homo sapiens)
- Rna polymerase ii (Complex from Sus scrofa)
- Cyclin-dependent kinase 7 (39 kDa, Protein from Homo sapiens)
- General transcription factor iie subunit 1 (49 kDa, Protein from Homo sapiens)
- P53-bound tfiid-based holo pic on hdm2 promoter (Complex)
- Dna (71-mer) (22 kDa, DNA from Homo sapiens)
- General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 11 (23 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from Sus scrofa)
- Transcription initiation factor tfiid subunit 9 (29 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from Sus scrofa)
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb1 (217 kDa, Protein from Homo sapiens)
- Rpb12 (7 kDa, Protein from Sus scrofa)
- Transcription initiation factor tfiid subunit 7 (40 kDa, Protein from Homo sapiens)
- Cyclin-h (37 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Sus scrofa)
- Rna_pol_l_2 domain-containing protein (13 kDa, Protein from Sus scrofa)
- Transcription initiation factor tfiid subunit 12 (17 kDa, Protein from Homo sapiens)
- Tfiia (Complex from Homo sapiens)
- General transcription factor iih subunit 4 (52 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 4 (110 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 2 (137 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 1 (212 kDa, Protein from Homo sapiens)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Tfiif (Complex from Homo sapiens)
- General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 3 (103 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 10 (21 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from Sus scrofa)
- Rpb10 (7 kDa, Protein from Sus scrofa)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Transcription initiation factor tfiid subunit 13 (14 kDa, Protein from Homo sapiens)
- Cdk-activating kinase assembly factor mat1 (35 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 6 (72 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit f (14 kDa, Protein from Sus scrofa)
- General transcription and dna repair factor iih helicase subunit xpd (87 kDa, Protein from Homo sapiens)
- Tfiid (Complex from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 8 (34 kDa, Protein from Homo sapiens)
- Dna (71-mer) (21 kDa, DNA from Homo sapiens)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7egh
Q-score: 0.481
Chen X, Qi Y, Wu Z, Wang X, Li J, Zhao D, Hou H, Li Y, Yu Z, Liu W, Wang M, Ren Y, Li Z, Yang H, Xu Y
Science (2021) 372 [ Pubmed: 33795473 DOI: doi:10.1126/science.aba8490 ]
- Tfiid lobe c subcomplex (Complex from Homo sapiens)
- Dna (45-mer) (22 kDa, DNA from Homo sapiens)
- Transcription initiation factor tfiid subunit 6 (72 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 2 (137 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 1 (212 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 7 (40 kDa, Protein from Homo sapiens)
- Transcription initiation factor tfiid subunit 8 (34 kDa, Protein from Homo sapiens)
- Dna (45-mer) (28 kDa, DNA from Homo sapiens)